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On-line Access: 2021-07-20
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Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration
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Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar. Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration[J]. Journal of Zhejiang University Science D, 2021, 4(4): 735-756.
@article{title="Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration",
author="Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="735-756",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00149-0"
}
%0 Journal Article
%T Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration
%A Haniyeh Najaf
%A Mahboobeh Jafari
%A Ghazal Farahavar
%A Samira Sadat Abolmaali
%A Negar Azarpira
%A Sedigheh Borandeh
%A Raheleh Ravanfar
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 735-756
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00149-0
TY - JOUR
T1 - Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration
A1 - Haniyeh Najaf
A1 - Mahboobeh Jafari
A1 - Ghazal Farahavar
A1 - Samira Sadat Abolmaali
A1 - Negar Azarpira
A1 - Sedigheh Borandeh
A1 - Raheleh Ravanfar
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 735
EP - 756
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00149-0
Abstract: The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially
in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that
provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are
ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based
hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major
self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic selfcomplementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention
is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on
molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.
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