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On-line Access: 2023-07-07
Received: 2022-09-12
Revision Accepted: 2023-01-31
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Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting
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Jirong Yang, Huimin He, Duo Li, Qian Zhang, Lizhi Xu & Changshun Ruan. Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting[J]. Journal of Zhejiang University Science D, 2023, 6(5): 586–608.
@article{title="Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting",
author="Jirong Yang, Huimin He, Duo Li, Qian Zhang, Lizhi Xu & Changshun Ruan",
journal="Journal of Zhejiang University Science D",
volume="6",
number="5",
pages="586–608",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00236-4"
}
%0 Journal Article
%T Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting
%A Jirong Yang
%A Huimin He
%A Duo Li
%A Qian Zhang
%A Lizhi Xu & Changshun Ruan
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 5
%P 586–608
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00236-4
TY - JOUR
T1 - Advanced strategies in the application of gelatin-based bioink for extrusion bioprinting
A1 - Jirong Yang
A1 - Huimin He
A1 - Duo Li
A1 - Qian Zhang
A1 - Lizhi Xu & Changshun Ruan
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 5
SP - 586–608
EP -
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00236-4
Abstract: The significance of bioink suitability for the extrusion bioprinting of tissue-like constructs cannot be overemphasized. Gelatin, derived from the hydrolysis of collagen, not only can mimic the extracellular matrix to immensely support cell function, but also is suitable for extrusion under certain conditions. Thus, gelatin has been recognized as a promising bioink for extrusion bioprinting. However, the development of a gelatin-based bioink with satisfactory printability and bioactivity to fabricate complex tissue-like constructs with the desired physicochemical properties and biofunctions for a specific biomedical application is still in its infancy. Therefore, in this review, we aim to comprehensively summarize the state-of-the-art methods of gelatin-based bioink application for extrusion bioprinting. We firstly outline the properties and requirements of gelatin-based bioinks for extrusion bioprinting, highlighting the strategies to overcome their main limitations in terms of printability, structural stability and cell viability. Then, the challenges and prospects are further discussed regarding the development of ideal gelatin-based bioinks for extrusion bioprinting to create complex tissue-like constructs with preferable physicochemical properties and biofunctions.
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