Full Text:
<818>
Summary: 
<341>
Suppl. Mater.: 
CLC number:
On-line Access: 2023-02-05
Received: 2022-07-01
Revision Accepted: 2022-09-04
Crosschecked: 2023-02-09
Cited: 0
Clicked: 1427
Citations: Bibtex RefMan EndNote GB/T7714
Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
| ||||||||||||||
Hanyu WANG, Yuanhao YANG, Xiao ZHANG, Yan WANG, Hui FAN, Jinfeng SHI, Xuelian TAN, Baoshi XU, Jingchao QIANG, Enzhuang PAN, Mingyi CHU, Zibo DONG, Jingquan DONG. Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model[J]. Journal of Zhejiang University Science B, 2023, 24(2): 185-190.
@article{title="Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model",
author="Hanyu WANG, Yuanhao YANG, Xiao ZHANG, Yan WANG, Hui FAN, Jinfeng SHI, Xuelian TAN, Baoshi XU, Jingchao QIANG, Enzhuang PAN, Mingyi CHU, Zibo DONG, Jingquan DONG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="2",
pages="185-190",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200340"
}
%0 Journal Article
%T Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
%A Hanyu WANG
%A Yuanhao YANG
%A Xiao ZHANG
%A Yan WANG
%A Hui FAN
%A Jinfeng SHI
%A Xuelian TAN
%A Baoshi XU
%A Jingchao QIANG
%A Enzhuang PAN
%A Mingyi CHU
%A Zibo DONG
%A Jingquan DONG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 2
%P 185-190
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200340
TY - JOUR
T1 - Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
A1 - Hanyu WANG
A1 - Yuanhao YANG
A1 - Xiao ZHANG
A1 - Yan WANG
A1 - Hui FAN
A1 - Jinfeng SHI
A1 - Xuelian TAN
A1 - Baoshi XU
A1 - Jingchao QIANG
A1 - Enzhuang PAN
A1 - Mingyi CHU
A1 - Zibo DONG
A1 - Jingquan DONG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 2
SP - 185
EP - 190
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200340
Abstract: sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.
[1]AliSS, AhsanH, ZiaMK, et al., 2020. Understanding oxidants and antioxidants: classical team with new players. J Food Biochem, 44(3):e13145.
[2]AroojM, ImranS, Inam-ur-RaheemM, et al., 2021. Lotus seeds (Nelumbinis semen) as an emerging therapeutic seed: a comprehensive review. Food Sci Nutr, 9(7):3971-3987.
[3]CaoC, YuMM,ChaiYF, 2019. Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell Death Dis, 10(10):782.
[4]HotchkissRS, TinsleyKW, SwansonPE, et al., 2001. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol, 166(11):6952-6963.
[5]KanhutuK, JonesP, ChengAC, et al., 2017. Spleen Australia guidelines for the prevention of sepsis in patients with asplenia and hyposplenism in Australia and New Zealand. Intern Med J, 47(8):848-855.
[6]KaurS, AllanSM, Al-AhmadyZS, 2022. Re-directing nanomedicines to the spleen: a potential technology for peripheral immunomodulation. J Control Release, 350:60-79.
[7]KimSY, MoonGS, 2015. Photoprotective effect of lotus (Nelumbo nucifera Gaertn.) seed tea against UVB irradiation. Prev Nutr Food Sci, 20(3):162-168.
[8]KumarS, GuptaE, KaushikS, et al., 2018. Evaluation of oxidative stress and antioxidant status: correlation with the severity of sepsis. Scand J Immunol, 87(4):e12653.
[9]LiangLP, YeSW, JiangRL, et al., 2022. Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling. Int Immunopharmacol, 104:108306.
[10]LiuFJ, GuTJ, WeiDY, 2022. Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-κB and HMGB1 pathways mediated by SIRT1. Kaohsiung J Med Sci, 38(3):253-260.
[11]ManogaranP, BeerakaNM, PadmaVV, 2019. The cytoprotective and anti-cancer potential of bisbenzylisoquinoline alkaloids from Nelumbo nucifera. Curr Top Med Chem, 19(32):2940-2957.
[12]RuddKE, JohnsonSC, AgesaKM, et al., 2020. Global, regional, and national sepsis incidence and mortality, 1990‒2017: analysis for the Global Burden of Disease Study. Lancet, 395(10219):200-211.
[13]ThompsonPN, ChoE, BlumenstockFA, et al., 1992. Liver and spleen phagocytic depression after peripheral ischemia and reperfusion. Am J Surg, 164(3):248-253.
[14]YuYY, SunSN, WangSF, et al., 2016. Liensinine- and neferine-induced cardiotoxicity in primary neonatal rat cardiomyocytes and human-induced pluripotent stem cell-derived cardiomyocytes. Int J Mol Sci, 17(2):186.
[15]ZhuMZ, LiuT, GuoMQ, 2016. Current advances in the metabolomics study on lotus seeds. Front Plant Sci, 7:891.
ORCID: 
Open peer comments: Debate/Discuss/Question/Opinion
<1>