Affiliation(s):
School of Mechatronics & Vehicle Engineering, East China Jiaotong University, Nanchang 330013, China;
Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, China;
Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China
Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang, Yong He. Rapid printing of 3D porous scaffolds for breast reconstruction[J]. Journal of Zhejiang University Science ,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-023-00046-X
@article{title="Rapid printing of 3D porous scaffolds for breast reconstruction", author="Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang, Yong He", journal="Journal of Zhejiang University Science ", year="in press", publisher="Zhejiang University Press & Springer", doi="https://doi.org/10.1007/s42242-023-00046-X" }
%0 Journal Article %T Rapid printing of 3D porous scaffolds for breast reconstruction %A Pengcheng Zhao %A Biling Wang %A Lu Wang %A Zexin Fu %A Jun Hu %A Yande Liu %A Ji Wang %A Yong He %J Journal of Zhejiang University SCIENCE %P %@ 2095-9184 %D in press %I Zhejiang University Press & Springer doi="https://doi.org/10.1007/s42242-023-00046-X"
TY - JOUR T1 - Rapid printing of 3D porous scaffolds for breast reconstruction A1 - Pengcheng Zhao A1 - Biling Wang A1 - Lu Wang A1 - Zexin Fu A1 - Jun Hu A1 - Yande Liu A1 - Ji Wang A1 - Yong He J0 - Journal of Zhejiang University Science SP - EP - %@ 2095-9184 Y1 - in press PB - Zhejiang University Press & Springer ER - doi="https://doi.org/10.1007/s42242-023-00046-X"
Abstract: Prosthesis implantation and fat transplantation are common breast reconstruction methods. In general, prosthesis implantation alone does not achieve a realistic enough appearance, and fat transplantation alone is difficult to achieve in the correct capacity. To date, no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction. Using a newly designed bionic ink (i.e., f127DA & PEGDA) and projection-based 3D bioprinting (PBP), we report the development of a new method for printing porous prostheses. PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of f127DA and reducing the impact of external temperature. The compression modulus of the printed prosthesis was very close to that of prostheses that are currently used in clinical practice and to that of natural breasts. Finally, stromal vascular fraction gel (SVF-gel), a human fat extract, was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue. These were implanted subcutaneously in nude mice to observe their biological performance. After 14 and 28 days of observation, the prosthesis showed good biocompatibility, and adipose tissues grew well in and around the prosthesis. This result shows that a porous prosthesis containing pre-placed adipose tissue is a promising breast reconstruction material.
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