JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Research advances in the function and anti-aging effects of nicotinamide mononucleotides

Author(s): Min WANG, Yuan CAO, Yun LI, Lu WANG, Yuyan LIU, Zihui DENG, Lianrong ZHU, Hongjun KANG
Affiliation(s): Medical School of Chinese PLA, Beijing 100853, China; more
Corresponding email(s): doctorkang301@163.com
Key Words: Nicotinamide mononucleotide (NMN); Anti-aging; Energy metabolism; apoptosis; DNA repair

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Min WANG,Yuan CAO, Yun LI, Lu WANG, Yuyan LIU, Zihui DENG, Lianrong ZHU, Hongjun KANG. Research advances in the function and anti-aging effects of nicotinamide mononucleotides[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300886

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author="Min WANG,Yuan CAO, Yun LI, Lu WANG, Yuyan LIU, Zihui DENG, Lianrong ZHU, Hongjun KANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300886"
}

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%A Lu WANG
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%A Zihui DENG
%A Lianrong ZHU
%A Hongjun KANG
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300886"

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A1 - Zihui DENG
A1 - Lianrong ZHU
A1 - Hongjun KANG
J0 - Journal of Zhejiang University Science B
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doi="https://doi.org/10.1631/jzus.B2300886"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task, with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases. Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide (NAD+) in the realm of anti-aging. It has been empirically evidenced that supplementation with nicotinamide mononucleotide (NMN) can elevate NAD+ levels in the body, thereby ameliorating certain age-related degenerative diseases. The principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism, inhibition of cell apoptosis, modulation of immune function, and preservation of genomic stability, which collectively contribute to the deferral of the aging process. This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN, elucidating the inherent limitations of current research, and proposing novel avenues for anti-aging investigations.

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