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On-line Access: 2021-08-05
Received: 2020-11-15
Revision Accepted: 2021-06-04
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Recent advances in the development of in vitro liver models for hepatotoxicity testing
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Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang . Recent advances in the development of in vitro liver models for hepatotoxicity testing[J]. Journal of Zhejiang University Science D, 2021, 4(4): 717-734.
@article{title="Recent advances in the development of in vitro liver models for hepatotoxicity testing",
author="Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang ",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="717-734",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00142-7"
}
%0 Journal Article
%T Recent advances in the development of in vitro liver models for hepatotoxicity testing
%A Siming Lu
%A Jingwei Zhang
%A Sha Lin
%A Danfeng Zheng
%A Yan Shen
%A Jiale Qin
%A Yangyang Li
%A Shuqi Wang
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 717-734
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00142-7
TY - JOUR
T1 - Recent advances in the development of in vitro liver models for hepatotoxicity testing
A1 - Siming Lu
A1 - Jingwei Zhang
A1 - Sha Lin
A1 - Danfeng Zheng
A1 - Yan Shen
A1 - Jiale Qin
A1 - Yangyang Li
A1 - Shuqi Wang
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 717
EP - 734
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00142-7
Abstract: liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical
treatment. If not properly treated, patients with severe liver injury can sufer from acute liver failure or even death. Thus,
utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is
vital for drug development and safe personalized medication. Biomaterials (e.g., hydrogels, nanofbers, decellularized liver
matrix) and bioengineering technologies (e.g., microarrays, micropatterns, 3D printing, and microfuidics) have been applied
for in vitro hepatotoxicity assessment models. This review summarizes the structure and functions of the liver as well as
the components of in vitro hepatotoxicity assessment models. In addition, it highlights the latest advances in developing
hepatotoxicity models with the ultimate goal of further clinical translation.
Open peer comments: Debate/Discuss/Question/Opinion
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