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Bio-Design and Manufacturing  2024 Vol.7 No.5 P.611-623

http://doi.org/10.1007/s42242-024-00298-y


Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips using Projection-Based 3D Printing


Author(s):  Mingjun Xie, Zexin Fu, Chunfei Lu, Sufan Wu, Lei Pan, Yong He, Yi Sun, Ji Wang

Affiliation(s):  Plastic and Reconstructive Surgery Center, Department of Plastic and Reconstructive Surgery, Zhejiang Provincial Peoples Hospital, Affiliated Peoples Hospital, Hangzhou Medical College, Hangzhou 310014, China; more

Corresponding email(s):   jiwang1004@zju.edu.cn (Ji Wang), yisun@zju.edu.cn (Yi Sun)

Key Words:  Paper-based microfluidic chip, Projection-based 3D printing (PBP), Modularization, Cell culture


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Mingjun Xie,Zexin Fu, Chunfei Lu, Sufan Wu, Lei Pan , Yong He, Yi Sun, Ji Wang. Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips using Projection-Based 3D Printing[J]. Journal of Zhejiang University Science D, 2024, 7(5): 611-623.

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author="Mingjun Xie,Zexin Fu, Chunfei Lu, Sufan Wu, Lei Pan , Yong He, Yi Sun, Ji Wang",
journal="Journal of Zhejiang University Science D",
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publisher="Zhejiang University Press & Springer",
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Abstract: 
Paper-based microchips have different advantages, such as better biocompatibility, simple production, and easy handling, which makes them promising candidates for clinical diagnosis and other fields. This study describes a method developed to fabricate modular three-dimensional (3D) paper-based microfluidic chips based on projection-based 3D printing (PBP) technology. A series of two-dimensional (2D) paper-based microfluidic modules was designed and fabricated. After evaluating the effect of exposure time on the accuracy of the flow channel, the resolution of this channel was experimentally analyzed. Furthermore, several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods, with good channel connectivity. Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible. Furthermore, by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips, multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paper-based microfluidic chips, confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.

浙江省人民医院整形外科谢明君、王吉等 | 基于投影式光固化3D打印方法的模块化纸基微流控芯片快速制造

本研究论文聚焦药物研发中缺少合适工具以及动物实验的伦理问题,提出了模块化纸芯片概念,有望成为药物研发新工具。纸质微芯片具有生物相容性好、制作简单、易操作等优势,成为临床诊断等领域的理想材料。本研究描述了一种基于投影式3D打印(PBP)技术开发模块化3D纸基微流控芯片的方法。设计并制作了一系列2D纸基微流控模块。在评估了曝光时间对流道精度的影响后,分析了该流道的分辨率。此外,通过不同的方法,在2D芯片的基础上组装了3D纸基微流控芯片,其流道连接性良好。验证了基于3D纸基微流控芯片的支架式2D细胞培养和水凝胶式3D细胞培养系统的可行性。此外,通过将挤出式生物3D打印技术与所提出的3D纸基微流控芯片相结合,通过在3D纸基微流控芯片上直接打印3D水凝胶结构,建立了多器官微流控芯片,这证实了所制备的模块化3D纸基微流控芯片在生物医学应用中具有潜在的应用前景。

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