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On-line Access: 2024-08-27
Received: 2023-10-17
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Enhancing angiogenesis and osseointegration through a double gyroid Ti6Al4V scaffold with triply periodic minimal surface
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Hao Liu, Hao Chen, Bin Sun, Danyang Fan, Aobo Zhang, Hanqiang Liu, Hexiang Wei, Wenbo Yang, Yongyue Li, Peng Xia, Qing Han, Jincheng Wang. Enhancing angiogenesis and osseointegration through a double gyroid Ti6Al4V scaffold with triply periodic minimal surface[J]. Journal of Zhejiang University Science D, 2025, 8(1): 36-54.
@article{title="Enhancing angiogenesis and osseointegration through a double gyroid
Ti6Al4V scaffold with triply periodic minimal surface",
author="Hao Liu, Hao Chen, Bin Sun, Danyang Fan, Aobo Zhang, Hanqiang Liu, Hexiang Wei, Wenbo Yang, Yongyue Li, Peng Xia, Qing Han, Jincheng Wang",
journal="Journal of Zhejiang University Science D",
volume="8",
number="1",
pages="36-54",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400114"
}
%0 Journal Article
%T Enhancing angiogenesis and osseointegration through a double gyroid
Ti6Al4V scaffold with triply periodic minimal surface
%A Hao Liu
%A Hao Chen
%A Bin Sun
%A Danyang Fan
%A Aobo Zhang
%A Hanqiang Liu
%A Hexiang Wei
%A Wenbo Yang
%A Yongyue Li
%A Peng Xia
%A Qing Han
%A Jincheng Wang
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 1
%P 36-54
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400114
TY - JOUR
T1 - Enhancing angiogenesis and osseointegration through a double gyroid
Ti6Al4V scaffold with triply periodic minimal surface
A1 - Hao Liu
A1 - Hao Chen
A1 - Bin Sun
A1 - Danyang Fan
A1 - Aobo Zhang
A1 - Hanqiang Liu
A1 - Hexiang Wei
A1 - Wenbo Yang
A1 - Yongyue Li
A1 - Peng Xia
A1 - Qing Han
A1 - Jincheng Wang
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 1
SP - 36
EP - 54
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400114
Abstract: The pore structure of porous scaffolds plays a crucial role in bone repair. The prevalent bone implant structure in clinical
practice is the traditional cubic structure. However, the traditional cubic structure exhibits sharp edges and junctions that are
not conducive to cell adhesion and growth. In this study, a double gyroid (DG) Ti6Al4V scaffold based on a triply periodic
minimal surface (TPMS) structure was devised, and the osseointegration performance of DG structural scaffolds with varying
porosities was investigated. Compression tests revealed that the elastic modulus and compressive strength of DG structural
scaffolds were sufficient for orthopedic implants. In vitro cellular experiments demonstrated that the DG structure signifi?
cantly enhanced cell proliferation, vascularization, and osteogenic differentiation compared to the cubic structure. The DG
structure with 55% porosity exhibited the most favorable outcomes. In vivo experiments in rabbits further demonstrated that
DG scaffolds could promote neovascularization and bone regeneration and maturation; those with 55% porosity performed
best. Comparing the surface area, specific surface area per unit volume, and internal flow distribution characteristics of
gyroid and DG structure scaffolds, the latter are more conducive to cell adhesion and growth within scaffolds. This study un?
derscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaf?
folds, inducing angiogenesis, and advancing the clinical application of titanium scaffolds for repairing bone defects.
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