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Polypeptide-modified BP nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke
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Meili Zhang, Taojian Fan, Shujiang Yin, Jie Li, Jing Hou, Ke Zhang, Bo Han, Wen Chen, Han Zhang, Xing Tian. Polypeptide-modified BP nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Polypeptide-modified BP nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke",
author="Meili Zhang, Taojian Fan, Shujiang Yin, Jie Li, Jing Hou, Ke Zhang, Bo Han, Wen Chen, Han Zhang, Xing Tian",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400175"
}
%0 Journal Article
%T Polypeptide-modified BP nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke
%A Meili Zhang
%A Taojian Fan
%A Shujiang Yin
%A Jie Li
%A Jing Hou
%A Ke Zhang
%A Bo Han
%A Wen Chen
%A Han Zhang
%A Xing Tian
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400175
TY - JOUR
T1 - Polypeptide-modified BP nanosheets as a brain-targeted
neuroprotective agent for treating ischemic stroke
A1 - Meili Zhang
A1 - Taojian Fan
A1 - Shujiang Yin
A1 - Jie Li
A1 - Jing Hou
A1 - Ke Zhang
A1 - Bo Han
A1 - Wen Chen
A1 - Han Zhang
A1 - Xing Tian
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400175
Abstract: ischemic stroke is the leading cause of death in China, accounting for approximately
one-third of all stroke-associated deaths worldwide. Currently, thrombolysis is employed for
Preprint of Bio-Design and Manufacturing (unedited)
ischemic strokes. However, due to the limited therapeutic window of thrombolytic agents, most
patients do not receive the drug at the right time. Moreover, these agents are associated with risks
of hemorrhage and reperfusion damage. Herein, ANG-BP-RES, a drug-loaded system, was used
to deliver drugs across the blood-brain barrier (BBB). ANG-BP-RES has a uniform size, stable
structure, good photothermal effect, and strong drug release ability under near-infrared (NIR)
irradiation and acidic conditions. Furthermore, ANG-BP-RES can efficiently target the brain and
improve BBB permeability, exerting a significant therapeutic effect against ischemic brain injury,
especially after NIR radiation. ANG-BP-RES is also biocompatible and shows minimal toxicity
toward cells and tissues. This study offers novel insights into the therapeutic management of
ischemic brain injury.
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