CLC number: R392
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Cited: 7
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ZHANG Wen-jin, ZHENG Shu-sen. In vitro study of immunosuppressive effect of apoptotic cells[J]. Journal of Zhejiang University Science B, 2005, 6(9): 919-925.
@article{title="In vitro study of immunosuppressive effect of apoptotic cells",
author="ZHANG Wen-jin, ZHENG Shu-sen",
journal="Journal of Zhejiang University Science B",
volume="6",
number="9",
pages="919-925",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0919"
}
%0 Journal Article
%T In vitro study of immunosuppressive effect of apoptotic cells
%A ZHANG Wen-jin
%A ZHENG Shu-sen
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 9
%P 919-925
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0919
TY - JOUR
T1 - In vitro study of immunosuppressive effect of apoptotic cells
A1 - ZHANG Wen-jin
A1 - ZHENG Shu-sen
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 9
SP - 919
EP - 925
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0919
Abstract: Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα), interleukin-1beta (IL-1β) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.
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