Full Text:   <2590>

CLC number: Q78; TP31

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 1

Clicked: 5662

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.11 P.782-786

http://doi.org/10.1631/jzus.2007.B0782


Using genetic markers in unpedigreed populations to detect a heritable trait


Author(s):  DODDS Ken G., AMER Peter R., AUVRAY Benoî,t

Affiliation(s):  Applied Biotechnologies Group, AgResearch Limited, Invermay Research Centre, Private Bag 50034, Mosgiel 9053, New Zealand; more

Corresponding email(s):   ken.dodds@agresearch.co.nz

Key Words:  Relatedness, Genetic markers, Heritable trait


DODDS Ken G., AMER Peter R., AUVRAY Benoît. Using genetic markers in unpedigreed populations to detect a heritable trait[J]. Journal of Zhejiang University Science B, 2007, 8(11): 782-786.

@article{title="Using genetic markers in unpedigreed populations to detect a heritable trait",
author="DODDS Ken G., AMER Peter R., AUVRAY Benoît",
journal="Journal of Zhejiang University Science B",
volume="8",
number="11",
pages="782-786",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0782"
}

%0 Journal Article
%T Using genetic markers in unpedigreed populations to detect a heritable trait
%A DODDS Ken G.
%A AMER Peter R.
%A AUVRAY Benoî
%A t
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 11
%P 782-786
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0782

TY - JOUR
T1 - Using genetic markers in unpedigreed populations to detect a heritable trait
A1 - DODDS Ken G.
A1 - AMER Peter R.
A1 - AUVRAY Benoî
A1 - t
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 11
SP - 782
EP - 786
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0782


Abstract: 
Before a breeder invests selection pressure on a trait of interest, it needs to be established whether that trait is actually heritable. Some traits may not have been measured widely in pedigreed populations, for example, a disease or deformity may become more prevalent than previously, but is still relatively rare. One approach to detect inheritance would be to screen a commercial population to obtain a sample of “affecteds” (the test group) and to also obtain a random control group. These individuals are then genotyped with a set of genetic markers and the relationships between individuals within each group estimated. If the relatedness is higher in the test group than in the control group, this provides initial evidence for the trait being heritable. A power simulation shows that this approach is feasible with moderate resources.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Ayres, K.L., Overall, A.D.J., 2004. Api-calc 1.0: a computer program for calculating the average probability of identity allowing for substructure, inbreeding and the presence of close relatives. Molecular Ecology Notes, 4(2):315-318.

[2] Balding, D.J., 2006. A tutorial on statistical methods for population association studies. Nature Reviews Genetics, 7(10):781-791.

[3] Blouin, M.S., 2003. DNA-based methods for pedigree reconstruction and kinship analysis in natural populations. Trends in Ecology and Evolution, 18(10):503-511.

[4] Coltman, D.W., 2005. Testing marker-based estimates of heritability in the wild. Molecular Ecology, 14(8):2593-2599.

[5] Manly, B.F.J., 1997. Randomization, Bootstrap and Monte Carlo Methods in Biology. Chapman & Hall, London, p.1-23.

[6] Milligan, B.G., 2003. Maximum-likelihood estimation of relatedness. Genetics, 163(3):1153-1167.

[7] Oliehoek, P.A., Windig, J.J., van Arendonk, J.A.M., Bijma, P., 2006. Estimating relatedness between individuals in general populations with a focus on their use in conservation programs. Genetics, 173(1):483-496.

[8] Queller, D.C., Goodnight, K.F., 1989. Estimating relatedness using genetic markers. Evolution, 43(2):258-275.

[9] Taberlet, P., Luikart, G., 1999. Non-invasive genetic sampling and individual identification. Biological Journal of the Linnean Society, 68(1-2):41-55.

[10] Thomas, S.C., 2005. The estimation of genetic relationships using molecular markers and their efficiency in estimating heritability in natural populations. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1459):1457-1467.

[11] Thomas, S.C., Hill, W.G., 2002. Sibship reconstruction in hierarchical population structures using Markov chain Monte Carlo techniques. Genetical Research, 79(3):227-234.

[12] van de Casteele, T., Galbusera, P., Matthysen, E., 2001. A comparison of microsatellite-based pairwise relatedness estimators. Molecular Ecology, 10(6):1539-1549.

[13] Wang, J., 2002. An estimator for pairwise relatedness using molecular markers. Genetics, 160(3):1203-1215.

[14] Weir, B.S., Anderson, A.D., Hepler, A.B., 2006. Genetic relatedness analysis: modern data and new challenges. Nature Reviews Genetics, 7(10):771-780.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE