Full Text:   <2066>

CLC number: TB131; Q274

On-line Access: 2011-03-09

Received: 2010-04-23

Revision Accepted: 2010-07-13

Crosschecked: 2011-02-17

Cited: 0

Clicked: 4802

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.3 P.210-218

http://doi.org/10.1631/jzus.B1010199


Moisture sorption characteristics of freeze-dried human platelets


Author(s):  Meng-jie Xu, Guang-ming Chen, Ju-li Fan, Jin-hui Liu, Xian-guo Xu, Shao-zhi Zhang

Affiliation(s):  Institute of Refrigeration and Cryogenics, Zhejiang University, Hangzhou 310027, China, College of Aerospace Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China, Key Laboratory of Blood Safety Research, Ministry of Health, Blood Center of Zhejiang Province, Hangzhou 310006, China

Corresponding email(s):   enezsz@zju.edu.cn

Key Words:  Human platelets, Freeze-drying, Sorption, Moisture


Meng-jie Xu, Guang-ming Chen, Ju-li Fan, Jin-hui Liu, Xian-guo Xu, Shao-zhi Zhang. Moisture sorption characteristics of freeze-dried human platelets[J]. Journal of Zhejiang University Science B, 2011, 12(3): 210-218.

@article{title="Moisture sorption characteristics of freeze-dried human platelets",
author="Meng-jie Xu, Guang-ming Chen, Ju-li Fan, Jin-hui Liu, Xian-guo Xu, Shao-zhi Zhang",
journal="Journal of Zhejiang University Science B",
volume="12",
number="3",
pages="210-218",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1010199"
}

%0 Journal Article
%T Moisture sorption characteristics of freeze-dried human platelets
%A Meng-jie Xu
%A Guang-ming Chen
%A Ju-li Fan
%A Jin-hui Liu
%A Xian-guo Xu
%A Shao-zhi Zhang
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 3
%P 210-218
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1010199

TY - JOUR
T1 - Moisture sorption characteristics of freeze-dried human platelets
A1 - Meng-jie Xu
A1 - Guang-ming Chen
A1 - Ju-li Fan
A1 - Jin-hui Liu
A1 - Xian-guo Xu
A1 - Shao-zhi Zhang
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 3
SP - 210
EP - 218
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1010199


Abstract: 
freeze-drying is a promising method for a long-term storage of human platelets. The moisture sorption characteristics of freeze-dried human platelets (FDHPs) were studied in this paper. The moisture sorption isotherms of FDHPs and freeze-dried lyophilization buffer (FDLB) were measured at 4, 25, and 37 °C. The experimental data were fitted to Brunauer-Emmett-Teller (BET) and Guggenheim-Anderson-de Boer (GAB) equations. There were no significant statistical differences (P>0.05) between the sorption characteristics of FDHPs and FDLB at 4 and 25 °C, while FDHPs absorbed more water at 37 °C. The net isosteric heat of sorption was derived. The heat for FDHPs showed an abnormal negative value at low moisture contents when 25 and 37 °C data were used. Dynamic sorption experiments were carried out at 25 °C with environmental water activity controlled at 0.75, 0.85, and 0.90. The moisture diffusion coefficient was fitted to be 8.24×10−12 m2/s when experimental data at initial time were used. These results would be helpful in choosing prehydration and storage condition for FDHPs.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Aldous, B.J., Auffret, A.D., Franks, F., 1995. The crystallization of hydrates from amorphous carbohydrates. Cryo-Letters, 16(3):181-186.

[2]Al-Muhtaseb, A.H., Mcminn, W.A.M., Magee, T.R.A., 2002. Moisture sorption isotherms characteristics of food products: a review. Food Biopr. Process., 80(2):118-128.

[3]Bode, A.P., Read, M.S., 2000. Lyophilized platelets: continued development. Transfusion Sci., 22(1-2):99-105.

[4]Burnett, D.J., Garcia, A.R., Thielmann, F., 2006. Technical note: measuring moisture sorption and diffusion kinetics on proton exchange membranes using a gravimetric vapor sorption apparatus. J. Power Sources, 160(1):426-430.

[5]Chen, T., Fowler, A., Toner, M., 2000. Literature review: supplemented phase diagram of the trehalose-water binary mixture. Cryobiology, 40(3):277-282.

[6]Columbano, A., Buckton, G., Wikeley, P., 2002. A study of the crystallisation of amorphous salbutamol sulphate using water vapour sorption and near infrared spectroscopy. Int. J. Pharm., 237(1-2):171-178.

[7]Crank, J., 1975. The Mathematics of Diffusion, 2nd Ed. Oxford University Press Inc., New York, USA, p.44-68.

[8]Fabra, M.J., Talens, P., Moraga, G., Martínez-Navarrete, N., 2009. Sorption isotherm and state diagram of grapefruit as a tool to improve product processing and stability. J. Food Eng., 93(1):52-58.

[9]Fan, J.L., Xu, X.G., Zhang, S.Z., Zhu, F.M., Chen, G.M., Yan, L.X., 2009. Experimental study on rehydration conditions of freeze-dried platelets. J. Zhejiang Univ.-Sci. A, 10(5):697-703.

[10]Gabas, A.L., Telis, V.R.N., Sobral, P.J.A., Romero, J.T., 2007. Effect of maltodextrin and arabic gum in water vapor sorption thermodynamic properties of vacuum dried pineapple pulp powder. J. Food Eng., 82(2):246-252.

[11]Greenspan, L., 1977. Humidity fixed points of binary saturated aqueous solutions. J. Res. Natl. Bureau Stand.-A. Phys. Chem., 81A(1):89-96.

[12]Guillard, V., Broyart, B., Bonazzi, C., Guilbert, S., Gontard, N., 2003. Modelling of moisture transfer in a composite food dynamic water properties in an intermediate aw porous product in contact with high aw filling. Chem. Eng. Res. Des., 81(9):1090-1098.

[13]Guillard, V., Broyart, B., Guilbert, S., Bonazzi, C., Gontard, N., 2004. Moisture diffusivity and transfer modelling in dry biscuit. J. Food Eng., 64(1):81-87.

[14]Marais, S., Metayer, M., Nguyena, T.Q., Labb, M., Perrinb, L., Saiter, J.M., 2000. Permeametric and microgravimetric studies of sorption and diffusion of water vapor in an unsaturated polyester. Polymer, 41(7):2667-2676.

[15]McLaughlin, C.P., Magee, T.R.A., 1998. The determination of sorption isotherm and the isosteric heats of sorption for potatoes. J. Food Eng., 35(3):267-280.

[16]McMinn, W.A.M., Magee, T.R.A., 1997. Moisture sorption characteristics of starch materials. Dry. Technol., 15(5):1527-1551.

[17]McMinn, W.A.M., Magee, T.R.A., 1999. Studies on the effect of temperature on themoisture sorption characteristics of potatoes. J. Food Process Eng., 22(2):113-128.

[18]McMinn, W.A.M., Magee, T.R.A., 2003. Thermodynamic properties of moisture sorption of potato. J. Food Eng., 60(2):157-165.

[19]Michelson, A.D., 2007. Platelets, 2nd Ed. Academic Press, San Diego, CA, USA, p.45-73.

[20]Modesti, M., Dall(Acqua, C., Lorenzetti, A., Florian, E., 2004. Mathematical model and experimental validation of water cluster influence upon vapour permeation through hydrophilic dense membrane. J. Membr. Sci., 229(1-2):211-223.

[21]Omar, E.A.M., Roos, Y.H., 2007. Water sorption and time-dependent crystallization behaviour of freeze-dried lactose-salt mixtures. LWT-Food Sci. Technol., 40(3):520-528.

[22]Pérez-Alonso, C., Beristain, C.I., Lobato-Calleros, C., Rodríguez-Huezo, M.E., Vernon-Carter, E.J., 2006. Thermodynamic analysis of the sorption isotherms of pure and blended carbohydrate polymers. J. Food Eng., 77(4):753-760.

[23]Perrin, L., Nguyen, Q.T., Clement, R., Neel, J., 1996. Sorption and diffusion of solvent vapours in poly(vinylalcohol) membranes of different crystallinity degrees. Polymer Int., 39(3):251-260.

[24]Salnikova, M.S., Middaugh, R., Rytting, J.H., 2008. Stability of lyophilized human growth hormone. Int. J. Pharm., 358(1-2):108-113.

[25]Sinija, V.R., Mishra, H.N., 2008. Moisture sorption isotherms and heat of sorption of instant (soluble) green tea powder and green tea granules. J. Food Eng., 86(4):494-500.

[26]Sitaula, R., Bhowmick, S., 2006. Moisture sorption characteristics and thermophysical properties of trehalose-PBS mixtures. Cryobiology, 52(3):369-385.

[27]Stasiak, M.W., Jamroz, J., 2008. Analysis of sorption properties of starch-protein extrudates with the use of water vapour. J. Food Eng., 85(4):580-589.

[28]Timmermann, E.O., Chirife, J., Iglesias, H.A., 2001. Water sorption isotherms of foods and foodstuffs: BET or GAB parameters? J. Food Eng., 48(1):19-31.

[29]van Drooge, D.J., Hinrichs, W.L.J., Visser, M.R., Frijlink, H.W., 2006. Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. Int. J. Pharm., 310(1-2):220-229.

[30]Wang, H.Y., Zhang, S.Z., Chen, G.M., 2008. Glass transition and state diagram for fresh and freeze-dried Chinese gooseberry. J. Food Eng., 84(2):307-312.

[31]Wolkers, W.F., Walker, N.J., Tablin, F., Crowe, J.H., 2001. Human platelets loaded with trehalose survive freeze-drying. Cryobiology, 42(2):79-87.

[32]Wolkers, W.F., Looper, S.A., Fontanilla, R.A., Tsvetkova, N.M., Tablin, F., Crowe, J.H., 2003. Temperature dependence of fluid phase endocytosis coincides with membrane properties of pig platelets. Biochim. Biophys. Acta Biomembr., 1612(2):154-163.

[33]Zeng, X.M., Martin, G.P., Marriott, C., 2001. Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose. Int. J. Pharm., 218(1-2):63-73.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE