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CLC number: TS207.5

On-line Access: 2012-07-05

Received: 2011-12-25

Revision Accepted: 2012-05-30

Crosschecked: 2012-06-17

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.7 P.525-532

http://doi.org/10.1631/jzus.B1100389


Recent developments in the detection of melamine


Author(s):  Yuan Liu, Ewen E. D. Todd, Qiang Zhang, Jiang-rong Shi, Xian-jin Liu

Affiliation(s):  Key Laboratory of Food Quality and Safety of Jiangsu Province, Nanjing 210014, China; more

Corresponding email(s):   liuyuan@jaas.ac.cn

Key Words:  Melamine, Detection, Confirmation methods, Screening methods, Sample pretreatment


Yuan Liu, Ewen E. D. Todd, Qiang Zhang, Jiang-rong Shi, Xian-jin Liu. Recent developments in the detection of melamine[J]. Journal of Zhejiang University Science B, 2012, 13(7): 525-532.

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DOI - 10.1631/jzus.B1100389


Abstract: 
In recent years, there were two reported outbreaks of food borne illness associated with melamine. The presence of melamine and its related compounds in milk, feed, and other foods has resulted in the need for reliable methods for the detection and accurate quantification of this class of contaminants. The sample pretreatment for melamine in a complex matrix usually involves a liquid extraction by a polar solvent, followed by a further clean-up with solid phase extraction. Analyses of melamine and related compounds are commonly carried out by liquid or gas chromatographic methods conjugated with mass spectrometry. Other innovative screening methods, which use antibodies, molecularly imprinted polymers, capillary electrophoresis, and gold nanoparticles, are also used to develop assays and biosensors to melamine. However, many of these methods have been hindered by matrix effects, the solubility of melamine-cyanuric acid complex, and background contamination. This article reviews recent developments for detecting melamine and discusses future directions.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Andersen, W.C., Turnipseed, S.B., Karbiwnyk, C.M., Clark, S.B., Madson, M.R., Gieseker, C.M., 2008. Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry. J. Agric. Food Chem., 56(12):4340-4347.

[2]AQSIQ (General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China), SAC (Standardization Administration of the People’s Republic of China), 2008a. GB/T 22288-2008. Determination of melamine, ammeline, ammelide and cyanuric acid in original plant products GC-MS method. Chinese Standards (in Chinese).

[3]AQSIQ, SAC, 2008b. GB/T 22388-2008. Determination of melamine in raw milk and dairy products. Chinese Standards (in Chinese).

[4]AQSIQ, SAC, 2008c. GB/T 22400-2008. Rapid determination of melamine in raw milk-liquid chromatographic method. Chinese Standards (in Chinese).

[5]Cao, Q., Zhao, H., Zeng, L.X., Wang, J., Wang, R., Qiu, X.H., He, Y.J., 2009. Electrochemical determination of melamine using oligonucleotides modified gold electrodes. Talanta, 80(2):484-488.

[6]Cheng, Y., Dong, Y.Y., Wu, J.H., Yang, X.R., Bai, H., Zheng, H.Y., Ren, D.M., Zou, Y.D., Li, M., 2010. Screening melamine adulterant in milk powder with laser Raman spectrometry. J. Food Comp. Anal., 23(2):199-202.

[7]Dane, A.J., Cody, R.B., 2010. Selective ionization of melamine in powdered milk by using argon direct analysis in real time (DART) mass spectrometry. Analyst, 135(4):696-699.

[8]Ding, T., Xu, J., Li, J., Shen, C., Wu, B., Chen, H., Li, S., 2008. Determination of melamine residue in plant origin protein powders using high performance liquid chromatography-diode array detection and high performance liquid chromatography-electrospray ionization tandem mass spectrometry. Sepu, 26:6-9.

[9]Ehling, S., Tefera, S., Ho, I.P., 2007. High-performance liquid chromatographic method for the simultaneous detection of the adulteration of cereal flours with melamine and related triazine by-products ammeline, ammelide, and cyanuric acid. Food Addit. Contam., 24(12):1319-1325.

[10]FDA (U.S. Food and Drug Administration), 2009a. Analytical Methods for Melamine and Triazine Analogs. Available from http://www.fda.gov/AnimalVeterinary/Science Research/ToolsResources/ucm135002.htm [accessed on May 21, 2011]

[11]FDA, 2009b. Melamine Pet Food Recall in 2007. Available from http://www.fda.gov/animalveterinary/safetyhealth/ recallswithdrawals/ucm 129575.htm [accessed on May 21, 2011]

[12]Feng, J.W., Cai, Q.R., Liu, X.C., Yu, Y.G., Peng, Y.F., Zhang, Y., 2008. Determination of melamine and cyromazine in milk and dairy products by LC-MS/MS. Mod. Food Sci. Technol., 24:1058-1060.

[13]Field, A., Field, J., 2010. Melamine and cyanuric acid do not interfere with Bradford and Ninhydrin assays for protein determination. Food Chem., 121(3):912-917.

[14]Filazi, A., Sireli, U.T., Ekici, H., Can, H.Y., Karagoz, A., 2012. Determination of melamine in milk and dairy products by high performance liquid chromatography. J. Dairy Sci., 95(2):602-608.

[15]Filigenzi, M.S., Tor, E.R., Poppenga, R.H., Aston, L.A., Puschner, B., 2007. The determination of melamine in muscle tissue by liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom., 21(24):4027-4032.

[16]Filigenzi, M.S., Puschner, B., Aston, L.R., Poppenga, R.H., 2008. Diagnostic determination of melamine and related compounds in kidney tissue by liquid chromatography/ tandem mass spectrometry. J. Agric. Food Chem., 56(17):7593-7599.

[17]Garber, E.A., 2008. Detection of melamine using commercial enzyme-linked immunosorbent assay technology. J. Food Prot., 71:590-594.

[18]Guo, L., Zhong, J., Wu, J., Fu, F., Chen, G., Zheng, X., Lin, S., 2010. Visual detection of melamine in milk products by label-free gold nanoparticles. Talanta, 82(5):1654-1658.

[19]Heller, D.N., Nochetto, C.B., 2008. Simultaneous determination and confirmation of melamine and cyanuric acid in animal feed by zwitterionic hydrophilic interaction chromatography and tandem mass spectrometry. Rapid Commun. Mass Spectrom., 22(22):3624-3632.

[20]Huang, H.Y., Lin, C.L., Jiang, S.H., Singco, B., Cheng, Y.J., 2012. Capillary electrochromatography mass spectrometry determination of melamine and related triazine by-products using poly(divinyl benzene-alkene-vinylbenzyl trimethylammonium chloride) monolithic stationary phases. Anal. Chim. Acta, 719:96-103.

[21]Ibáñez, M., Sancho, J.V., Hernández, F., 2009. Determination of melamine in milk-based products and other food and beverage products by ion-pair liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta, 649(1):91-97.

[22]Karbiwnyk, C.A., Andersen, W.C., Turnipseed, S.B., Storey, J.M., Madson, M.R., Miller, K.E., Gieseker, C.M., Miller, R.A., Rummel, N.G., Reimschuessel, R., 2009. Determination of cyanuric acid residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta, 637(1-2):101-111.

[23]Kim, B., Perkins, L.B., Bushway, R.J., 2008. Determination of melamine in pet food by enzyme immunoassay, high-performance liquid chromatography with diode array detection and ultra-performance liquid chromatography with tandem mass spectrometry. J. AOAC Int., 91:408-413.

[24]Kuang, H., Chen, W., Yan, W., Xu, L., Zhu, Y., Liu, L., Chu, H., Peng, C., Wang, L., Kotov, N.A., et al., 2011. Crown ether assembly of gold nanoparticles: melamine sensor. Biomed. Environ. Sci., 26:2032-2037.

[25]Lei, H.T., Shen, Y.D., Song, L.J., Yang, J.Y., Chevallier, O.P., Haughey, S.A., Wang, H., Sun, Y.M., Elliott, C.T., 2010. Hapten synthesis and antibody production for the development of a melamine immunoassay. Anal. Chim. Acta, 665(1):84-90.

[26]Li, J., Qia, H.Y., Shi, Y.P., 2009. Determination of melamine residues in milk products by zirconia hollow fiber sorptive microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A, 1216(29):5467-5471.

[27]Li, J.P., Chen, Z.Q., Li, Y.P., 2011. A strategy for constructing sensitive and renewable molecularly imprinted electrochemical sensors for melamine detection. Anal. Chim. Acta, 706(2):255-260.

[28]Lin, M., He, L., Awika, J., Yang, L., Ledoux, D.R., Li, H., Mustapha, A., 2008. Detection of melamine in gluten, chicken feed, and processed foods using surface enhanced Raman spectroscopy and HPLC. J. Food Sci., 73(8):T129-T134.

[29]Liu, J.X., Zhong, Y.B., Liu, J., 2010. An enzyme linked immunosorbent assay for the determination of cyromazine and melamine residues in animal muscle tissues. Food Control, 21(11):1482-1487.

[30]Look Back '08:10 Big Events in CHINA (II), 2008. China Daily. Available from http://www.chinadaily.com.cn/china/ 2008-12/31/content_7357389.htm [accessed on Apr. 6, 2009]

[31]Mauer, L.J., Chernyshova, A.A., Hiatt, A., Deering, A., Davis, R., 2009. Melamine detection in infant formula powder using near- and mid-infrared spectroscopy. J. Agric. Food Chem., 57(10):3974-3980.

[32]Miao, H., Fan, S., Wu, Y.N., Zhang, L., Zhou, P.P., Li, J.G., Chen, H.J., Zhao, Y.F., 2009. Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry. Biomed. Environ. Sci., 22(2):87-94.

[33]Muñiz-Valencia, R., Ceballos-Magaña, S.G., Rosales-Martinez, D., Gonzalo-Lumbreras, R., Santos-Montes, A., Cubedo-Fernandez-Trapiella, A., Izquierdo-Hornillos, R.C., 2008. Method development and validation for melamine and its derivatives in rice concentrates by liquid chromatography. Application to animal feed samples. Anal. Bioanal. Chem., 392(3):523-531.

[34]Panuwet, P., Nguyen, J.V., Wade, E.L., D′Souza, P.E., Ryan, P.B., Barr, D.B., 2012. Quantification of melamine in human urine using cation-exchange based high performance liquid chromatography tandem mass spectrometry. J. Chromatogr. B, 887-888:48-54.

[35]Ping, H., Zhang, M,W., Li, H.K., Li, S.G., Chen, Q.S., Sun, C.Y., Zhang, T.H., 2012. Visual detection of melamine in raw milk by label-free silver nanoparticles. Food Control, 23(1):191-197.

[36]Rima, J., Abourida, M., Xu, T., Cho, K., Kyriacos, S., 2009. New spectrophotometric method for the quantitative determination of melamine using Mannich reaction. J. Food Comp. Anal., 22(7-8):689-693.

[37]Smoker, M., Krynitsky, A.J., 2008. Interim Method for Determination of Melamine and Cyanuric Acid Residues in Foods Using LC-MS/MS: Version 1.0. U.S. Food and Drug Administration (FDA). Available from http:// www.fda.gov/Food/ScienceResearch/LaboratoryMethods/DrugChemicalResiduesMethodology/ucm071673.htm [accessed on Oct. 10, 2011]

[38]Squadrone, S., Ferro, G.L., Mauro, D.M.C., 2010. Determination of melamine in feed: validation of a gas chromatography-mass spectrometry method according to 2004/882/ CE regulation. Food Control, 21(5):714-718.

[39]Sun, F.X., Ma, W., Xu, L.G., Zhu, Y.Y., Liu, L.Q., Peng, C.F., Wang, L.B., Kuang, K., Xu, C.L., 2010. Analytical methods and recent developments in the detection of melamine. TrAC, 29(11):1239-1294.

[40]Sun, H.W., Wang, L.X., Ai, L.F., Liang, S.X., 2010. A sensitive and validated method for determination of melamine residue in liquid milk by reversed phase high-performance liquid chromatography with solid-phase extraction. Food Control, 21(5):686-691.

[41]Tittlemier, S.A., 2010. Methods for the analysis of melamine and related compounds in foods: a review. Food Addit. Contam., 27(2):129-145.

[42]Tsai, I.L., Sun, S.W., Liao, H.W., 2009. Rapid analysis of melamine in infant formula by sweeping-micellar electrokinetic chromatography. J. Chromatogr. A, 1216(47):8296-8303.

[43]Varelis, P., Jeskelis, R., 2008. Preparation of [13C3]-melamine and [13C3]-cyanuric acid and their application to the analysis of melamine and cyanuric acid in meat and pet food using liquid chromatography-tandem mass spectrometry. Food. Addit. Contam., 25(10):1208-1215.

[44]Venkatasami, G., Sowa, R.J.J., 2010. A rapid, acetonitrile-free, HPLC method for determination of melamine in infant formula. Anal. Chim. Acta, 665(2):227-230.

[45]Wang, Q., Haughey, S.A., Sun, Y.M., Eremin, S.A., Li, Z.F., Liu, H., Xu, Z.L., Shen, Y.D., Lei, H.T., 2011. Development of a fluorescence polarization immunoassay for the detection of melamine in milk and milk powder. Anal. Bioanal. Chem., 399(6):2275-2284.

[46]Wei, F., Lam, R., Cheng, S., Lu, S., Ho, D., Li, N., 2010. Rapid detection of melamine in whole milk mediated by unmodified gold nanoparticles. Appl. Phys. Lett., 96(13):133702.

[47]WHO (World Health Organization), 2009a. Background paper on methods for the analysis of melamine and related compounds in foods andanimal feeds. Available from http://www.who.int/topics/melamine/en [accessed on May 12, 2011]

[48]WHO (World Health Organization), 2009b. Toxicological and health aspects of melamine and cyanuric acid. Available from http://www.who.int/topics/melamine/en [accessed on May 12, 2011]

[49]Wu, Y.T., Huang, C. M., Lina, C.C., Ho, W.A., Lin, L.C., Chiu, T.F., Tarn, D.C., Lin, C.H., Tsai, T.H., 2009. Determination of melamine in rat plasma, liver, kidney, spleen, bladder and brain by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A, 1216(44):7595-7601.

[50]Xia, J.G., Zhou, N.Y., Liu, Y.J., Chen, B., Wu, Y.N., Yao, S.Z., 2010. Simultaneous determination of melamine and related compounds by capillary zone electrophoresis. Food Control, 21(6):912-918.

[51]Xia, X., Ding, S.Y., Li, X.W., Gong, X., Zhang, S.X., Jiang, H.Y., Li, J.C., Shen, J.Z., 2009. Validation of a confirmatory method for the determination of melamine in egg by gas chromatography-mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta, 651(2):196-200.

[52]Xu, X.M., Ren, Y.P., Zhu, Y., Cai, Z.X., Han, J.L., Huang, B.F., Zhu, Y., 2009. Direct determination of melamine in dairy products by gas chromatography/mass spectrometry with coupled column separation. Anal. Chim. Acta, 650(1):39-43.

[53]Yang, H.H., Zhou, W.H., Guo, X.C., Chen, F.R., Zhao, H.Q., Lin, L.M., Wang, X.R., 2009. Molecularly imprinted polymer as SPE sorbent for selective extraction of melamine in dairy products. Talanta, 80(2):821-825.

[54]Yang, S.P., Ding, J.H., Zheng, J., Hu, B., Li, J.Q., Chen, H.W., Zhou, Z.Q., Qiao, X.L., 2009. Detection of melamine in milk products by surface desorption atmospheric pressure chemical ionization mass spectrometry. Anal. Chem., 81(7):2426-2436.

[55]Yu, J.H., Zhang, C.C., Dai, P., Shen, G.G., 2009. Highly selective molecular recognition and high throughput detection of melamine based on molecularly imprinted sol-gel film. Anal. Chim. Acta, 651(2):209-214.

[56]Zhai, C., Qiang,W., Sheng, J., Lei, J.P., Ju, H.X., 2010. Pretreatment-free fast ultraviolet detection of melamine in milk products with a disposable microfluidic device. J. Chromatogr. A, 1217(5):785-789.

[57]Zheng, X.L., Yu, B.S., Li, K.X., Dai, Y.N., 2012. Determination of melamine in dairy products by HILIC-UV with NH2 column. Food Control, 23(1):245-250.

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