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CLC number: R681.5

On-line Access: 2018-07-04

Received: 2017-10-05

Revision Accepted: 2017-11-05

Crosschecked: 2018-06-06

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Citations:  Bibtex RefMan EndNote GB/T7714


Yue Wang


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.7 P.547-558


Methodology and cohort profile for the Hangzhou Lumbar Spine Study: a study focusing on back health in a Chinese population

Author(s):  Xiao-jian Hu, Lun-hao Chen, Michele C. Battié, Yue Wang

Affiliation(s):  Spine Lab, Department of Orthopedic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   wangyuespine@zju.edu.cn

Key Words:  Back pain, Population-based study, Disc degeneration, Modic change, Endplate lesion, Methodology

Xiao-jian Hu, Lun-hao Chen, Michele C. Battié, Yue Wang. Methodology and cohort profile for the Hangzhou Lumbar Spine Study: a study focusing on back health in a Chinese population[J]. Journal of Zhejiang University Science B, 2018, 19(7): 547-558.

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author="Xiao-jian Hu, Lun-hao Chen, Michele C. Battié, Yue Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Methodology and cohort profile for the Hangzhou Lumbar Spine Study: a study focusing on back health in a Chinese population
%A Xiao-jian Hu
%A Lun-hao Chen
%A Michele C. Battié
%A Yue Wang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 7
%P 547-558
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700484

T1 - Methodology and cohort profile for the Hangzhou Lumbar Spine Study: a study focusing on back health in a Chinese population
A1 - Xiao-jian Hu
A1 - Lun-hao Chen
A1 - Michele C. Battié
A1 - Yue Wang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 7
SP - 547
EP - 558
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700484

back pain is a worldwide health problem, adding a tremendous burden to modern societies. However, little information on back health is available in China, even though a quarter of the world’s population is Chinese. To enhance knowledge in this area, we designed and initiated the Hangzhou Lumbar Spine Study, which is a cross-sectional study of a general sample of mainland Chinese with focusing on disc degeneration, modic changes, endplate lesions, and back pain. The study consists of a structured questionnaire to measure back pain history and lifetime exposure to suspected risk factors, magnetic resonance imaging of the lumbar spine, bone mineral density study of the spine and hip, and DNA sample analysis. Here we briefly introduce the study methodology, report the test-retest reliability of the questionnaire, and describe the cohort profile to date. Since May 2014, 301 randomly selected subjects (male/female, 122/179; mean age, 51.0 years; range, 20–87 years) have been recruited. Tests-retests of the questionnaire, completed by 40 participants, revealed good reliability. To our knowledge, the Hangzhou Lumbar Spine Study is the first population-based epidemiological study conducted to characterize lumbar spinal phenotypes and back pain, their interaction, and their associations with lifetime environmental exposure, in mainland Chinese. Epidemiological information obtained from a reliable questionnaire, magnetic resonance (MR) imaging data, dual energy X-ray absorptiometry (DXA) measurements, and DNA analysis may serve as a valuable reference for future studies on back health, particularly for mainland Chinese.


创新点:开展了中国大陆第一个基于大样本的有关腰痛、腰椎间盘退变、终板病损、Modic改变的流行病学研究;开发了一份可信度高的包含腰痛病史以及相关风险因素的调查问卷;采用高分辨率3.0 T核磁共振来分辨腰椎病变特征.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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