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On-line Access: 2019-07-05

Received: 2018-07-10

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.8 P.687-692

http://doi.org/10.1631/jzus.B1800373


Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia


Author(s):  Radosław Wieczór, Anna Maria Wieczór, Arleta Kulwas, Grzegorz Pulkowski, Jacek Budzyński, Danuta Rość

Affiliation(s):  Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz PL 85-094, Poland; more

Corresponding email(s):   wieczorcmumk@tlen.pl

Key Words:  Intermittent claudication, Critical limb ischemia, Vascular endothelial growth factor, Metalloproteinase


Radosław Wieczór, Anna Maria Wieczór, Arleta Kulwas, Grzegorz Pulkowski, Jacek Budzyński, Danuta Rość. Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia[J]. Journal of Zhejiang University Science B, 2019, 20(8): 687-692.

@article{title="Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia",
author="Radosław Wieczór, Anna Maria Wieczór, Arleta Kulwas, Grzegorz Pulkowski, Jacek Budzyński, Danuta Rość",
journal="Journal of Zhejiang University Science B",
volume="20",
number="8",
pages="687-692",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800373"
}

%0 Journal Article
%T Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia
%A Radosław Wieczór
%A Anna Maria Wieczór
%A Arleta Kulwas
%A Grzegorz Pulkowski
%A Jacek Budzyński
%A Danuta Rość
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 8
%P 687-692
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800373

TY - JOUR
T1 - Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia
A1 - Radosław Wieczór
A1 - Anna Maria Wieczór
A1 - Arleta Kulwas
A1 - Grzegorz Pulkowski
A1 - Jacek Budzyński
A1 - Danuta Rość
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 8
SP - 687
EP - 692
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800373


Abstract: 
The objective of this study was to assess the angiogenic potential expressed as a quotient of vascular endothelial growth factor A (VEGF-A), as an indicator of proangiogenic activity, and the circulating receptors (soluble VEGF receptor protein R1 (sVEGFR-1) and sVEGFR-2), as indicators of the effect of angiogenic inhibition, depending on the concentrations of matrix metalloproteinase 2 (MMP-2) and MMP-9 and their tissue inhibitor 1 (TIMP-1) and TIMP-2 in the plasma of patients with lower extremity artery disease (LEAD). These blood parameters in patients with intermittent claudication (IC) and critical limb ischemia (CLI) were compared for select clinical and biochemical features. Stimulation of angiogenesis in the plasma of individuals with LEAD was evident as indicated by the significant increase in VEGF-A concentration along with reduced inhibition depending on circulating receptors sVEGFR-1 and sVEGFR-2. Critical ischemia was associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 concentrations than in the case of IC.

严重肢体缺血患者血浆中促血管生成潜力与血浆MMP-9、TIMP-1和TIMP-2水平升高的相关性研究

概要:本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会显著增加,同时依赖于循环受体sVEGFR-1和sVEGFR-2的抑制也会显著减少.与IC病人相比,CLI病人具有较高的VEGF-A、金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)和TIMP-2浓度.
关键词:严重肢体缺血;间歇性跛行;血管内皮生长因子;金属蛋白酶

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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[26]List of electronic supplementary materials

[27]Table S1 Characteristics of the study group

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