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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.437-448

http://doi.org/10.1631/jzus.B1900150


O-GlcNAcylation, a sweet link to the pathology of diseases


Author(s):  Hao Nie, Wen Yi

Affiliation(s):  MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   wyi@zju.edu.cn

Key Words:  O-GlcNAcylation, Cancer, Diabetes, Neurodegenerative disease, Cardiovascular disease


Hao Nie, Wen Yi. O-GlcNAcylation, a sweet link to the pathology of diseases[J]. Journal of Zhejiang University Science B, 2019, 20(5): 437-448.

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author="Hao Nie, Wen Yi",
journal="Journal of Zhejiang University Science B",
volume="20",
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pages="437-448",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900150"
}

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%T O-GlcNAcylation, a sweet link to the pathology of diseases
%A Hao Nie
%A Wen Yi
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%DOI 10.1631/jzus.B1900150

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DOI - 10.1631/jzus.B1900150


Abstract: 
O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus, cytoplasm, and mitochondria. The donor sugar for O-GlcNAcylation, uridine-diphosphate N-acetylglucosamine (UDP-GlcNAc), is synthesized from glucose through the hexosamine biosynthetic pathway (HBP). The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which catalyze the addition and removal of O-GlcNAc, respectively. O-GlcNAcylation is involved in a number of important cell processes including transcription, translation, metabolism, signal transduction, and apoptosis. Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention. The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases, and its potential as a new clinical target.

O-GlcNAc修饰与疾病病理学的联系

概要:O-连接的N-乙酰葡萄糖胺(O-GlcNAc)修饰是一种发生于蛋白质丝氨酸或苏氨酸残基上的蛋白翻译后修饰,它能动态地发生在细胞的任何部位,如细胞质、线粒体、细胞核等.O-GlcNAc修饰的供体尿苷二磷酸-N-乙酰葡萄糖胺(UDP-GlcNAc)是己糖胺生物合成途径(HBP)的终产物.GlcNAc在蛋白上的添加和移除分别需要O-GlcNAc转移酶(OGT)和O-GlcNAc水解酶(OGA)的介导.被O-GlcNAc修饰的蛋白包括转录因子、代谢酶、细胞信号传导因子等.O-GlcNAc通过调控这些蛋白的功能参与到许多重要的生物进程中,如转录、翻译、代谢、信号传导、自噬等.此外,O-GlcNAc修饰的失调还与许多重要疾病息息相关,包括癌症、糖尿病、神经退行性疾病和心血管疾病.更好地了解O-GlcNAc修饰在这些疾病生理病理学进程中所起的作用将有助于开发新的治疗策略.本文介绍了O-GlcNAc与疾病病理联系的最新研究,并揭示O-GlcNAc可作为潜在的临床治疗靶点.
关键词:O连接的N-乙酰葡萄糖胺(O-GlcNAc);癌症;糖尿病;神经退行性疾病;心血管疾病

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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