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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.437-448


O-GlcNAcylation, a sweet link to the pathology of diseases

Author(s):  Hao Nie, Wen Yi

Affiliation(s):  MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   wyi@zju.edu.cn

Key Words:  O-GlcNAcylation, Cancer, Diabetes, Neurodegenerative disease, Cardiovascular disease

Hao Nie, Wen Yi. O-GlcNAcylation, a sweet link to the pathology of diseases[J]. Journal of Zhejiang University Science B, 2019, 20(5): 437-448.

@article{title="O-GlcNAcylation, a sweet link to the pathology of diseases",
author="Hao Nie, Wen Yi",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T O-GlcNAcylation, a sweet link to the pathology of diseases
%A Hao Nie
%A Wen Yi
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 5
%P 437-448
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900150

T1 - O-GlcNAcylation, a sweet link to the pathology of diseases
A1 - Hao Nie
A1 - Wen Yi
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 5
SP - 437
EP - 448
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900150

O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus, cytoplasm, and mitochondria. The donor sugar for O-GlcNAcylation, uridine-diphosphate N-acetylglucosamine (UDP-GlcNAc), is synthesized from glucose through the hexosamine biosynthetic pathway (HBP). The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which catalyze the addition and removal of O-GlcNAc, respectively. O-GlcNAcylation is involved in a number of important cell processes including transcription, translation, metabolism, signal transduction, and apoptosis. Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention. The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases, and its potential as a new clinical target.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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