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On-line Access: 2022-08-12
Received: 2021-11-02
Revision Accepted: 2022-04-01
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Citations: Bibtex RefMan EndNote GB/T7714
Junying GAO, Yan MA, Guiwen YANG, Guorong LI. Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2100910 @article{title="Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects", %0 Journal Article TY - JOUR
翻译控制肿瘤蛋白促进癌症侵袭和迁移及其潜在的临床前景山东师范大学生命科学学院,山东省动物抗性重点实验室,中国济南市,250014 概要:翻译控制肿瘤蛋白(TCTP)定位于真核细胞的细胞质和细胞核,是一种高度保守的多功能蛋白。它以外泌体的方式分泌,通过泛素-蛋白酶体系统(UPS)、热休克蛋白27(Hsp27)和分子伴侣介导的自噬(CMA)发生降解。TCTP的结构包含3个α-螺旋和11个β-链,并以螺旋发夹作为其结构特征。TCTP与蛋氨酸-R-亚砜还原酶B(MsrB)和哺乳动物Sec4抑制蛋白家族(Mss4/Dss4)的结构有很强的相似性,这些蛋白家族对小分子GTPase发挥鸟嘌呤核苷酸交换因子(GEF)的活性,表明TCTP的某些功能可能依赖于GEF的活性。TCTP对Rheb发挥GEF活性以促进果蝇细胞的生长和增殖。TCTP增强细胞分裂控制蛋白42(Cdc42)的表达从而促进癌细胞的侵袭和迁移。此外,TCTP通过与肌动蛋白微丝(MF)和微管(MT)蛋白结合来调控细胞骨架重排,并参与诱导上皮-间充质转化(EMT)的过程。因此,TCTP促进癌细胞运动。TCTP在癌组织中通常高表达,这减少了患者的存活率,然而药物能靶向TCTP会降低其促癌作用。本文综述了TCTP促进癌细胞侵袭和迁移的机制,并介绍了目前在癌症中抑制TCTP的策略。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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