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On-line Access: 2022-07-06
Received: 2021-11-25
Revision Accepted: 2022-03-14
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Qirong SHEN, Quan HE, Yuanjiang PAN, Cuirong SUN. Detection, isolation, and characterization of a novel impurity from several folic acid products[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2100970 @article{title="Detection, isolation, and characterization of a novel impurity from several folic acid products", %0 Journal Article TY - JOUR
叶酸产品中一种新杂质的检测、分离和结构表征1浙江大学药学院,中国杭州,310058 2浙江大学化学系,中国杭州,310027 3杭州仟源保灵药业有限公司,中国杭州,310018 概要:叶酸是一种重要的营养物质,常用于孕妇和婴幼儿人群的食品强化和营养补充。在叶酸产品的生产和储运过程中,常会产生一些杂质,其中大部分已获得结构鉴定,其中一些已被收录入药典。本研究报道了一种新的叶酸杂质K,该杂质存在于多种叶酸产品中。本研究采用制备型高效液相色谱对该杂质进行了成功分离,并采用多维核磁共振谱、高分辨质谱、傅里叶红外光谱和紫外光谱等分析手段,对其化学结构进行了鉴定。结果显示,该杂质是药典记载的叶酸杂质D的同分异构体,经结构分析,推测其为叶酸杂质G的水解产物。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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