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On-line Access: 2022-07-06
Received: 2021-12-08
Revision Accepted: 2022-05-03
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Zhaohui CAO, Di HUANG, Cifei TANG, Min ZENG, Xiaobo HU. PFKL, a novel regulatory node for NOX2-dependent oxidative burst and NETosis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2101029 @article{title="PFKL, a novel regulatory node for NOX2-dependent oxidative burst and NETosis", %0 Journal Article TY - JOUR
磷酸果糖激酶L调节NADPH氧化酶-2依赖的氧化爆发和中性粒细胞的炎性死亡1南华大学衡阳医学院生物化学与分子生物学教研室,中国衡阳市,421001 2南华大学衡阳医学院湖南省教育厅生态环境与重大疾病防治重点实验室,中国衡阳市,421001 概要:中性粒细胞胞外诱捕网(NETs),由活化的中性粒细胞释放的组蛋白和抗菌蛋白修饰的网状DNA纤维组成。中性粒细胞产生NETs,实现宿主防御作用,这一过程被称为中性粒细胞炎性死亡(NETosis)。NETosis是一把双刃剑,在应对各种外界刺激时,NETosis介导免疫反应,捕获和清除病原体,促进中性粒细胞和吞噬细胞的吞噬作用。然而,过度的NETosis增加炎症反应,持续炎症状态。因此,抑制异常NETosis的发生可以降低各种自身免疫性疾病和炎症性疾病的严重程度。磷酸果糖激酶L(PFKL)通过选择性激活中性粒细胞中的糖酵解通路,减少还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)产生,继而减少活性氧(ROS)的产生,抑制NETosis,为一些炎性疾病治疗提供新思路。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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