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On-line Access: 2022-12-15
Received: 2022-04-11
Revision Accepted: 2022-08-11
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Linghui HU, Wei WU, Jun ZOU. Circular RNAs: typical biomarkers for bone-related diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200211 @article{title="Circular RNAs: typical biomarkers for bone-related diseases", %0 Journal Article TY - JOUR
环状RNA:骨相关疾病的典型生物标志物上海体育学院运动科学学院,中国上海,200438 概要:骨是一种在人体中具有重要功能的结缔组织。细胞和细胞外基质(Extracellular matrix,ECM)是骨骼的关键组成部分,与骨相关疾病密切相关。然而,常规方法治疗骨相关疾病的结果并不乐观,因此需要通过阐明骨相关疾病的确切调控机制,寻找用于疾病诊断和治疗的新型生物标志物。环状RNA(Circular RNA,circRNA)是一种具有闭合环状结构的没有5’端或3’端多环腺苷酸尾的单链RNA。由于其高稳定性,circRNA有望成为典型的生物标志物。并且越来越多的证据表明circRNA参与调控骨相关疾病,包括骨关节炎、骨质疏松、骨肉瘤、多发性骨髓瘤、椎间盘退变和类风湿关节炎。本文综述了近年来circRNA特性和功能的研究进展,重点阐述了circRNA在骨相关疾病中的调控机制。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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