Abstract: To study the function of transforming growth factor β₁ (TGF-β₁) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β₁ ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β₁ between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β₁ secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β₁, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.

Key words: colorectal adenomas,TGF-β1,TGF-βR II,immunohistochemistry

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