Abstract: To study the relationship between gastrointestinal dysfunction and motilin in patients with hypot- hyroidism. The plasma motilin concentration was measured by radiommunoassay(RIA) in 30 patients with hypothyroidism and also in 30 controls. At the same time, the electrogastroenterogram was also taken. Among the hypothyroidism patients, 56.6% had decreased gastric motility, especially in gastric body and greater gastric curvature; 86.6 % had decreased colonic motility, especially in the left half of the colon. There were no significant differences of plasma motilin concentration between patients with hypothyroidism and controls (P>0.05). There were also no differences between pre-treatment and pest-treatment individuals, but significant differences were observed in the electrogastroenterogram. We conclude that the plasma motilin eoncertration in hypothyroidism patients was the same as that in normal patients, and that electrogastmenterogram studies in patients with gastrointestinal dysfunction may be valuable.

Key words: hypothyroidism, motilin, electrogastroenterogram

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