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Journal of Zhejiang University SCIENCE A
ISSN 1673-565X(Print), 1862-1775(Online), Monthly
2002 Vol.3 No.2 P.151-156
Mathematical model of the dynamics of countercurrent chromatography
Abstract: A mathematical model of the dynamic behavior of countercurrent chromatography was proposed, and the model parameters, including the partition coefficient, the axial dispersion coefficient, the intraparticle diffusion coefficient and the external mass ransfer coefficient were calculated by the method of chromatogram moment analysis. Comparison of the experimental chromatograms of caffeine and theophylline determined in this work with the simulated curves computed by the proposed model showed fairly good agreement. Further, the difference between the average identified the partition coefficients by chromatogram moment analysis and the experimental values was small also, and the relationship between the external mass transfer rate and the linear velocity was similar to that obtained with solid-liquid chromatography.
Key words: Countercurrent chromatography, Model simulation, Caffeine, Theophylline
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DOI:
10.1631/jzus.2002.0151
CLC number:
TQ018
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Received:
2001-04-16
Revision Accepted:
2001-09-04
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