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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2006 Vol.7 No.12 P.969-973

Regularities in the E. coli promoters composition in connection with the DNA strands interaction and promoter activity

BEREZHNOY Andrey Yu, SHCKORBATOV Yuriy G., HISANORI Kiryu

National Scientific Center, Kharkov Physical-Technical Institute, Kharkov 61108, Ukraine; Institute of Biology, Kharkov National University, Maidan Svobody 4, Kharkov 61077, Ukraine; Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Koto-ku Tokyo 135-0064, Japan

Yury.G.Shckorbatov@univer.kharkov.ua

Abstract: The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters) of promoters distributed by the energy of DNA strands interaction in −55, −35, −10 and +6 sequences indicates their connection with the transcriptional activity.

Key words: DNA sequence, Promoter strength, DNA chains interaction energy, DNA sequences classification


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DOI:

10.1631/jzus.2006.B0969

CLC number:

Q75

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Received:

2006-05-11

Revision Accepted:

2006-09-26

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