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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Investigation on the resilient modulus of soil mixture at various water contents and coarse grain contents under train moving loads

Abstract: Interlayer soil in railway substructures is characterized by a fine/coarse soil mixture. Considering that the resilient modulus Mr of the mixture is influenced by the microstructure of fine soil, it is worthwhile to investigate this aspect further. In this study, the microstructure of fines was explored by mercury intrusion porosimetry (MIP), and its influence on the Mr of the mixture was studied by multi-stage dynamic triaxial tests with varying deviator stress amplitudes σd. The results showed a fine matrix fabric obtained at water contents of fine soil wf=17.6% and 13.7% (>the plastic limit of fine soil wp=12%), and a fine aggregate fabric identified at wf=10.6% (<wp=12%). Interestingly, the influences of wf and σd on the Mr of the mixture were observed: the rise in σd contributed to a decline in Mr when wf>wp but to an increase in Mr when wf<wp. It was concluded that, for the fine matrix fabric (wf>wp), increasing σd induced a reduction in Mr, while for the fine aggregate fabric (wf<wp), increasing σd gave rise to the growth of Mr. The distinct Mr-σd behaviors for these two fabrics were explained by the competing influences between soil hardening upon loading and soil rebounding upon unloading. For the fine matrix fabric (wf>wp), considering its high deformability, the rebounding effect on Mr outweighed the hardening effect, and thus a decline in Mr occurred with the growth of σd. Conversely, for the fine aggregate fabric (wf<wp), the rebounding effect on Mr was secondary compared with the hardening effect based on the consideration of its low deformability, and thus an increase in Mr was observed with rising σd.

Key words: Railway engineering; Resilient modulus; Unsaturated soil; Microstructure

Chinese Summary  <13> 免疫检查点阻断的癌症治疗:最新进展与展望

叶弘颖1,2,廖炜杰1,2,潘炯利1,2,诗音3,王青青1,2
1浙江大学医学院免疫学研究所,中国杭州市,310058
2浙江省免疫与炎症疾病重点实验室,中国杭州市,310058
3浙江大学医学院生物化学系,中国杭州市,310058
摘要:抗肿瘤免疫反应的功能缺陷对癌症进展至关重要。免疫检查点阻断(ICB)可增强T细胞反应,是宿主抗肿瘤免疫正常化的有效策略。近年来,多项表达于肿瘤细胞和免疫细胞的免疫检查点已被鉴定,其中一些显示出良好的成药性,并已获得美国食品药品监督管理局(FDA)的批准用于临床治疗。然而,有限的治疗反应和免疫相关不良事件(irAEs)不容忽视。本文综述了ICB的发展和应用,并就基于ICB的癌症免疫疗法克服耐药性的潜在策略和未来方向展开讨论。

关键词组:免疫检查点阻断;癌症免疫疗法;肿瘤免疫逃逸;免疫正常化


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DOI:

10.1631/jzus.A2300492

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On-line Access:

2025-01-02

Received:

2023-10-03

Revision Accepted:

2023-12-26

Crosschecked:

2025-01-02

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