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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Rail profile optimization through balancing of wear and fatigue

Abstract: Rail profile optimization is a critical strategy for mitigating wear and extending service life. However, damage at the wheel-rail contact surface goes beyond simple rail wear, as it also involves fatigue phenomena. Focusing solely on wear and not addressing fatigue in profile optimization can lead to the propagation of rail cracks, the peeling of material off the rail, and even rail fractures. Therefore, we propose an optimization approach that balances rail wear and fatigue for heavy-haul railway rails to mitigate rail fatigue damage. Initially, we performed a field investigation to acquire essential data and understand the characteristics of track damage. Based on theory and measured data, a simulation model for wear and fatigue was then established. Subsequently, the control points of the rail profile according to cubic non-uniform rational B-spline (NURBS) theory were set as the research variables. The rail’s wear rate and fatigue crack propagation rate were adopted as the objective functions. A multi-objective, multi-variable, and multi-constraint nonlinear optimization model was then constructed, specifically using a Levenberg Marquardt-back propagation neural network as optimized by the particle swarm optimization algorithm (PSO-LM-BP neural network). Ultimately, optimal solutions from the model were identified using a chaos microvariation adaptive genetic algorithm, and the effectiveness of the optimization was validated using a dynamics model and a rail damage model.

Key words: Heavy-haul railway; Rail wear; Rail fatigue; Levenberg Marquardt-back propagation neural network as optimized by the particle swarm optimization algorithm (PSO-LM-BP neural network); Rail profile optimization; Multi-objective optimization

Chinese Summary  <8> 黄芩素作为抗寄生虫药剂在体外和体内对弓形虫的治疗作用

吴松睿1,5, 赖映梅1, 张忠澳1, 丁建祖1,2,3, 陆绍红1,2,3, 叶华跃4, 丁豪杰1,2,3, 卓洵辉1,2,3
1杭州医学院基础医学与法医学学院, 中国杭州市, 310013
2杭州医学院浙江省新型疫苗工程研究中心, 中国杭州市, 310000
3杭州医学院浙江省生物技术疫苗重点实验室, 中国杭州市, 310000
4国泰(台州)兽药生物制品技术创新中心, 中国台州市, 318000
5自贡市卫生健康委员会, 中国自贡市, 643000
摘要:乙胺嘧啶和磺胺嘧啶是目前治疗人畜共患弓形虫病最常用的药物,由于二者可能引发严重的不良反应,因此亟需寻找新的治疗药物。黄芩素(baicalein, BAI)已被证实对原生动物寄生虫(如利什曼原虫和隐孢子虫)具有良好的治疗效果。本研究通过斑块、侵袭和细胞内增殖试验评估BAI对刚地弓形虫的抑制效果。结果显示,BAI能有效抑制弓形虫的生长,其半数最大抑制浓度(IC50)为6.457×10?5 mol/L,显著降低了病原体的侵袭率(降低33.56%)及其在细胞内的增殖能力。此外,BAI具有较低的细胞毒性,其半数最大毒性浓度(TC50)为5.929×10?4 mol/L。ICR小鼠模型的实验结果进一步阐明了BAI对弓形虫的抑制作用,并揭示了其在抗寄生虫作用中的潜在机制。与阴性对照组相比,BAI处理显著延长了感染弓形虫小鼠的存活时间,并显著降低了肝脏和脾脏中的寄生虫负荷;活体切片的组织病理学检查结果显示,BAI处理组的治疗效果良好,未观察到明显病理性改变。此外,细胞因子水平的变化结果表明,BAI不仅能有效抑制弓形虫的生长,还能缓解小鼠过度的炎症反应。综上所述,本研究明确了BAI在治疗弓形虫感染方面具有显著的抑制作用,有望作为治疗弓形虫病的潜在替代药剂。

关键词组:刚地弓形虫;黄芩素;抗寄生虫药剂;免疫调节


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DOI:

10.1631/jzus.A2400235

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On-line Access:

2025-10-25

Received:

2024-05-06

Revision Accepted:

2024-06-27

Crosschecked:

2025-10-27

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