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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Computational analysis of Ti-6Al-4V thoracic implants with a spring-like geometry for anterior chest wall reconstruction

Abstract: Thoracic reconstructions are essential surgical techniques used to replace severely damaged tissues and restore protection to internal organs. In recent years, advancements in additive manufacturing have enabled the production of thoracic implants with complex geometries, offering more versatile performance. In this study, we investigated a design based on a spring-like geometry manufactured by laser powder bed fusion (LPBF), as proposed in earlier research. The biomechanical behavior of this design was analyzed using various isolated semi-ring-rib models at different levels of the rib cage. This approach enabled a comprehensive examination, leading to the proposal of several implant configurations that were incorporated into a 3D rib cage model with chest wall defects, to simulate different chest wall reconstruction scenarios. The results revealed that the implant design was too rigid for the second rib level, which therefore was excluded from the proposed implant configurations. In chest wall reconstruction simulations, the maximum stresses observed in all prostheses did not exceed 38% of the implant material’s yield stress in the most unfavorable case. Additionally, all the implants showed flexibility compatible with the physiological movements of the human thorax.

Key words: Chest wall reconstruction; Thoracic implant; Spring-like geometry; Semi-ring-rib model; Computational analysis

Chinese Summary  <12> 肠道菌群在维系肠道免疫稳态中的重要作用

涂舒谕1,张雅楠2,张莉1,朱书2
1广东药科大学附属第一医院心血管内科,中国广州市,510080
2浙江大学动物科学学院动物预防医学研究所,中国杭州市,310058
摘要:肠道中种类庞杂的微生物群落统称为肠道菌群,其与宿主间相互影响,形成了复杂的共生体系统。肠道菌群与动物健康关系密切,具有消化、合成维生素以及合成其他重要代谢物和神经递质的功能。多项研究表明,菌群相关代谢产物可通过直接或间接方式调节宿主的生理功能和免疫反应,以维持局部及全身的稳态平衡。我们利用葡聚糖硫酸钠诱导的结肠炎小鼠模型证实,肠道共生细菌纽约杜伯氏菌及其人类同源菌无害梭菌,可通过产生短链脂肪酸(特别是丙酸)和赖氨酸调节免疫耐受,从而缓解结肠炎。赖氨酸可通过芳烃受体激活树突状细胞中的吲哚胺2,3-双加氧酶1(IDO1),诱导调节性T淋巴细胞(Treg)产生免疫抑制的肠道微环境,该研究可为炎症性肠病提供一种潜在的治疗策略。

关键词组:肠道菌群;炎症性肠病;病毒-细菌互作;免疫调节


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DOI:

10.1631/jzus.A2400431

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On-line Access:

2025-07-29

Received:

2024-09-02

Revision Accepted:

2024-12-08

Crosschecked:

2025-07-29

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