Publishing Service

Polishing & Checking

Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

Stable and continuous vertical jumping control of hydraulic legged robots through reinforcement learning

Abstract: Hydraulic legged robots have potential for high-dynamic motion due to their large power-to-weight ratios. However, it is challenging to ensure both stability and continuity in the motion of such robots. In this study, we propose a jumping motion control framework based on deep reinforcement learning that enables hydraulic limb leg units to perform stable and continuous jumping motions. First, to accurately represent the performance of a physical prototype, a quasi-realistic model incorporating physical feasibility constraints is constructed. This model is informed by analysis of the relevant fluid dynamics, and incorporates a trajectory generator and a motion tracking controller. To achieve stable and continuous jumping performance, a deep reinforcement learning algorithm is developed, which jointly optimizes the trajectory generator and the motion tracking controller. Through validation on the physical prototype, we demonstrate that the proposed method reduces the maximum deviation and the average deviation by over 47% and 60%, respectively, and improves landing compliance by up to 7.7% compared to a baseline optimization algorithm, the non-dominated sorting genetic algorithm (NSGA-II). The proposed control framework may serve as a reference for high-dynamic motion control of legged robots and multi-objective optimization across several decision variables.

Key words: Legged robot; Deep reinforcement learning; Quasi-realistic modelling; Hydraulic system; Jumping control

Chinese Summary  <116> 苦瓜素I通过靶向核糖体蛋白诱导内质网应激抑制口腔鳞状细胞癌

孔建鲁1,朱子羽1,胡屹杰1,周思怡1,顾天忆1,沈枭2,王慧明1,俞梦飞1,刘宇1
1浙江大学医学院附属口腔医院,浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,中国杭州市,310006
2浙江中医药大学第二临床医学院,中国杭州市,310053
摘要:口腔鳞状细胞癌(OSCC)是全球最常见的恶性肿瘤之一,目前亟需开发高效、低毒且耐受性良好的创新药物。据报道,苦瓜提取物对OSCC具有显著的抗癌活性。在本研究中,我们采用细胞计数试剂盒-8(CCK-8)增殖实验和Transwell迁移实验评估了苦瓜提取物中九种三萜类化合物对OSCC的影响。结果显示,苦瓜素I(MI)在九种化合物中表现出最强的抗OSCC活性。进一步的动物实验也证实,MI在体内能抑制OSCC细胞的生长。此外,MI可降低线粒体膜电位并促进OSCC细胞的凋亡。通过RNA 测序(RNA-seq)分析发现,MI能诱导未折叠蛋白反应(UPR)和内质网(ER)应激,这一结果经蛋白质印迹(western blotting)和实时荧光定量逆转录聚合酶链反应(RT-qPCR)验证得到确认。随后,我们联合细胞热位移分析(CETSA)、质谱(MS)分析及分子对接技术,鉴定出核糖体蛋白(RPL7、RPL11、RPL12、RPL18、RPL30、RPL38、RPS13和RPS25)是MI的作用靶点。我们推测,MI通过靶向核糖体蛋白,能够破坏核糖体介导的蛋白质折叠,从而引发UPR和ER应激。综上,MI通过靶向核糖体蛋白诱导ER应激抑制OSCC细胞的生长,表明其具有良好的治疗潜力。

关键词组:口腔鳞状细胞癌(OSCC);苦瓜素I(MI);内质网(ER)应激;核糖体蛋白


Share this article to: More

Go to Contents

References:

<Show All>

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





DOI:

10.1631/jzus.A2500142

CLC number:

Download Full Text:

Click Here

Downloaded:

2137

Download summary:

<Click Here> 

Downloaded:

593

Clicked:

2109

Cited:

0

On-line Access:

2026-01-12

Received:

2025-04-23

Revision Accepted:

2025-07-29

Crosschecked:

2026-01-12

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952276; Fax: +86-571-87952331; E-mail: jzus@zju.edu.cn
Copyright © 2000~ Journal of Zhejiang University-SCIENCE