References:

<HIDE>

[1]Adhami, V.M., Siddiqui, J.A., Ahmad, N., et al., 2004. Oral consumption of 5 green tea polyphenols inhibits insulin-like growth factor-l-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res., 64(23):8715-8722.

[2]Arab, L., Biggs, M.L., O’Meara, E.S., et al., 2011. Gender differences in tea, coffee and cognitive decline in the elderly: the cardiovascular health study. J. Alzheimer’s Dis., 27(3):553-566.

[3]Arts, I.C., 2008. A review of the epidemiological evidence on tea, flavonoids, and lung cancer. J. Nutr., 138(8):1561S-1566S.

[4]Auvichayapat, P., Prapochanung, M., Tunkamnerdthai, O., et al., 2008. Effectiveness of green tea on weight reduction in obese Thais: a randomized controlled trial. Physiol. Behav., 93(3):486-491.

[5]Barranco, Q.J.L., Allam, M.F., del Castillo, A.S., et al., 2009. Parkinson’s disease and tea: a quantitative review. J. Am. Coll. Nutr., 28(1):1-6.

[6]Bastianetto, S., Han, Y.S., Rémi, Q., 2005. Green tea and resveratrol as protective agents against neurotoxins. In: Luo, Y., Packer, L. (Eds.), Oxidative Stress and Age-Related Neurodegeneration. CRC Press, Boca Raton, FL, USA, p.225-234.

[7]Basu, A., Sanchez, K., Leyva, N.M., et al., 2011. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition, 27(2):206-213.

[8]Bérubé-Parent, S., Pelletier, C., Doré, J., et al., 2005. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br. J. Nutr., 94(3):432-436.

[9]Bettuzzi, S., Brausi, M., Rizzi, F., et al., 2006. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res., 66(2):1234-1240.

[10]Boehm, K., Borrelli, F., Ernst, E., et al., 2009. Green tea for the prevention of cancer. Cochrane Database Syst. Rev., CD005004.

[11]Bøhn, S.K., Ward, N.C., Hodgson, J.M., et al., 2012. Effects of tea and coffee on cardiovascular disease risk. Food Funct., 3(6):575-591.

[12]Bohn, T., 2014. Dietary factors affecting polyphenol bio-availability. Nutr. Rev., 72(7):429-452.

[13]Bonner, M.R., Rothman, N., Mumford, J.L., et al., 2005. Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer. Mutat. Res. Gen. Toxicol. Envir. Mutag., 582(1-2):53-60.

[14]Chan, C.C., Kao, M.W., Ng, E.H., et al., 2006. Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome—a randomized placebo-controlled trial. J. Soc. Gynecol. Investig., 13(1):63-68.

[15]Chang, C.S., Chang, Y.F., Liu, P.Y., et al., 2012. Smoking, habitual tea drinking and metabolic syndrome in elderly men living in rural community: the Tianliao old people (TOP) study 02. PLoS ONE, 7(6):e38874.

[16]Chantre, P., Lairon, D., 2002. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine, 9(1):3-8.

[17]Checkoway, H., Powers, K., Smith-Weller, T., et al., 2002. Parkinson’s disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am. J. Epidemiol., 155(8):732-738.

[18]Chen, L., Lee, M.J., Li, H., et al., 1997. Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab. Dispos., 25(9):1045-1050.

[19]Clement, Y., 2009. Can green tea do that? A literature review of the clinical evidence. Prev. Med., 49(2-3):83-87.

[20]Dai, Q., Shu, X.O., Li, H., et al., 2010. Is green tea drinking associated with a later onset of breast cancer? Ann. Epidemiol., 20(1):74-81.

[21]da Silva Pinto, M., 2013. Tea: a new perspective on health benefits. Food Res. Int., 53(2):558.

[22]Deka, A., Vita, J.A., 2011. Tea and cardiovascular disease. Pharmacol. Res., 64(2):136-145.

[23]de Koning Gans, J.M., Uiterwaal, C.S., van der Schouw, Y.T., et al., 2010. Tea and coffee consumption and cardiovascular morbidity and mortality. Aterioscler. Thromb. Vasc. Biol., 30(8):1665-1671.

[24]Dufresne, C.J., Farnworth, E.R., 2001. A review of latest research findings on the health promotion properties of tea. J. Nutr. Biochem., 12(7):404-421.

[25]Fassina, G., Venè, R., Morini, M., et al., 2004. Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate. Clin. Cancer Res., 10(14):4865-4873.

[26]Feng, L., Ng, T.P., Kua, E.H., et al., 2013. Tea and the cognitive function of elderly people: evidence from neurobiology and epidemiology. In: Preedy, V.R. (Ed.), Tea in Health and Disease Prevention. AP Press, London, p.1325-1336.

[27]Fujiki, H., Imai, K., Nakachi, K., et al., 2012. Challenging the effectiveness of green tea in primary and tertiary cancer prevention. J. Cancer Res. Clin. Oncol., 138(8):1259-1270.

[28]Galanis, D.J., Kolonel, L.N., Lee, J., et al., 1998. Intakes of selected foods and beverages and the incidence of gastric cancer among the Japanese residents of Hawaii: a prospective study. Int. J. Epidemiol., 27(2):173-180.

[29]Gao, Y.T., McLaughlin, J.K., Blot, W.J., 1994. Reduced risk of esophageal cancer associated with green tea consumption. J. Natl. Cancer Inst., 86(11):855-858.

[30]Grundy, S.M., Cleeman, J.I., Daniels, S.R., et al., 2005. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112(17):2735-2752.

[31]Gupta, S., Hastak, K., Ahmad, N., et al., 2001. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. PNAS, 98(18):10350-10355.

[32]Henning, S.M., Wang, P.W., Heber, D., 2011. Chemopreventive effects of tea in prostate cancer: green tea versus black tea. Mol. Nutr. Food Res., 55(6):905-920.

[33]Hosoda, K., Wang, M.F., Liao, M.L., et al., 2003. Antihypeglyceic effect of Oolong tea in type-2 diabetes. Diab. Care, 26(6):1714-1718.

[34]Hsu, Y.W., Tsai, C.F., Chen, W.K., et al., 2011. A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice. Food Chem. Toxicol., 49(10):2624-2631.

[35]Hu, G., Bidel, S., Jousilshti, P., et al., 2007. Coffee and tea consumption and the risk of Parkinson’s disease. Mov. Disord., 22(15):2242-2248.

[36]Huang, X., Tajima, K., Hamajima, N., et al., 1999. Effect of life styles on the risk of subsite-specific gastric cancer in those with and without family history. J. Epidemiol., 9(1):40-45.

[37]Hursel, R., Viechtbauer, W., Dulloo, A.G., et al., 2011. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes. Rev., 12(7):573-581.

[38]Huxley, R., Lee, C.M., Barzi, F., et al., 2009. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch. Intern. Med., 169(22):2053-2063.

[39]Inoue, M., Tajima, K., Hirose, K., et al., 1998. Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. Cancer Causes Control, 9(2):209-216.

[40]Inoue, M., Robien, K., Wang, R., et al., 2008. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenensis, 29(10):1967-1972.

[41]Isbrucker, R.A., Bausch, J., Edwards, J.A., et al., 2006a. Safety studies on epigallocatechin-3-gallate (EGCG) preparations. Part 1: genotoxicity. Food Chem. Toxicol., 44(5):626-635.

[42]Isbrucker, R.A., Edwards, J.A., Wolz, E., et al., 2006b. Safety studies on epigallocatechin-3-gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem. Toxicol., 44(5):636-650.

[43]Isbrucker, R.A., Bausch, J., Edwards, J.A., et al., 2006c. Safety studies on epigallocatechin-3-gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats. Food Chem. Toxicol., 44(5):651-661.

[44]Iso, H., Date, C., Wakai, K., et al., 2006. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann. Int. Med., 144(8):554-562.

[45]Iwasaki, M., Inoue, M., Sasazuki, S., et al., 2010. Green tea drinking and subsequent risk of breast cancer in a population to based cohort of Japanese women. Breast Cancer Res., 12(5):R88.

[46]Jäger, A.K., Saaby, L., 2011. Flavonoids and the CNS. Molecules, 16(2):1471-1485.

[47]Ju, J., Hong, J., Zhou, J.N., et al., 2005. Inhibition of intestinal tumorigenesis in Apc^min/+ mice by (−)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res., 65(22):10623-10631.

[48]Kakuda, T., 2011. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacol. Res., 64(2):162-168.

[49]Kanwar, J., Taskeen, M., Mohammad, I., et al., 2012. Recent advances on tea polyphenols. Front. Biosci., 4(1):111-131.

[50]Kim, S., Lee, M.J., Hong, J., et al., 2000. Plasma and tissue levels of tea catechins in rats and mice during chronic consumption of green tea polyphenols. Nutr. Cancer, 37(1):41-48.

[51]Komatsu, T., 2003. Oolong tea increases energy metabolism in Japanese females. J. Med. Invest., 50(3-4):170-175.

[52]Kovacs, E.M., Lejeune, M.P., Nijs, I., et al., 2004. Effects of green tea on weight maintenance after body-weight loss. Br. J. Nutr., 91(3):431-437.

[53]Krishna, Y.R., Mittal, V., Grewal, P., et al., 2011. Acute liver failure caused by ‘fat burners’ and dietary supplements: a case report and literature review. Can. J. Gastroenterol., 25(3):157-160.

[54]Kumazoe, M., Sugihara, K., Tsukamoto, S., et al., 2013. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest., 123(2):787-799.

[55]Kurahashi, N., Sasazuki, S., Iwasaki, M., et al., 2008. Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am. J. Epidemiol., 167(1):71-77.

[56]Kuriyama, S., Shimazu, T., Ohmori, K., et al., 2006. Green tea consumption and mortality due to cardiovascular disease, cancer and all causes in Japan: the Ohsaki study. JAMA, 296(10):1255-1265.

[57]Lambert, J.D., Lee, M.J., Lu, H., et al., 2003. Epigallocatechin-3-gallate is absorbed but extensively gucuronidated following oral administration to mice. J. Nutr., 133(12):4172-4177.

[58]Lambert, J.D., Sang, S., Hong, J., et al., 2006. Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate. Drug Metab. Dispos., 34(12):2111-2116.

[59]Lambert, J.D., Sang, S., Lu, A.Y., et al., 2007. Metabolism of dietary polyphenols and possible interactions with drugs. Curr. Drug Metab., 8(5):499-507.

[60]Lambert, J.D., Kennett, M.J., Sang, S., et al., 2010. Hepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice. Food Chem. Toxicol., 48(1):409-416.

[61]Landis-Piwowar, K.R., Huo, C.D., Chen, D., et al., 2007. Methylation suppresses the proteasome-inhibitory function of green tea polyphenols. J. Cell. Physiol., 213(1):252-260.

[62]Lee, M.J., Maliakal, P., Chen, L., et al., 2002. Pharmacokinetics of tea catechins after ingestion of green tea and (−)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol. Biomarkers Prev., 11(10 Pt 1):1025-1032.

[63]Lee, S.R., Im, K.J., Suh, S.I., et al., 2003. Protective effect of green tea polyphenol (−)-epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates. Phytother. Res., 17(3):206-209.

[64]Lee, W.J., Shim, J.Y., Zhu, B.T., 2005. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol. Pharmacol., 68(4):1018-1030.

[65]Leong, H., Mathur, P.S., Geene, G.L., 2008. Inhibition of mammary tumorigenesis in the C3(1)/SV40 mouse model by green tea. Breast Cancer Res. Treat., 107(3):359-369.

[66]Li, F.J., Ji, H.F., Shen, L., 2012. A meta-analysis of tea drinking and risk of Parkinson’s disease. Sci. World J., 923464.

[67]Li, Q., Kakizuki, M., Kuriyama, S., et al., 2008. Green tea consumption and lung cancer risk: the Ohsaki study. Br. J. Cancer, 99(7):1179-1184.

[68]Lipinski, C.A., Lombardo, F., Dominy, B.W., et al., 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and developmental settings. Adv. Drug Deliv. Rev., 46(1-3):3-25.

[69]Lu, G., Xiao, H., You, H., et al., 2008. Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atrovastatin. Clin. Cancer Res., 14(15):4981-4988.

[70]Mair, V.H., Hoh, E., 2009. The True History of Tea. Thames Hudson, London.

[71]Maki, K.C., Reeves, M.S., Farmer, M., et al., 2009. Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J. Nutr., 139(2):264-270.

[72]Mazzanti, G., Menniti-Ippolito, F., Moro, P.A., et al., 2009. Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur. J. Clin. Pharmacol., 65(4):331-341.

[73]Mineharu, Y., Koizumi, A., Wada, Y., et al., 2011. Coffee, green tea, black tea and Oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. J. Epidemiol. Community Health, 65(3):230-240.

[74]Myung, S.K., Bae, W.K., Oh, S.M., et al., 2009. Green tea consumption and risk of stomach cancer: a meta-analysis of epidemiologic studies. Int. J. Cancer, 124(3):670-677.

[75]Nagano, J., Kono, S., Preston, D.L., et al., 2001. A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan). Cancer Causes Control, 12(6):501-508.

[76]Nagao, T., Komine, Y., Soga, S., et al., 2005. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am. J. Clin. Nutr., 81(1):122-129.

[77]Nagao, T., Hase, T., Tokimitsu, I., 2007. A green tea extract high in catechins reduces body fat and cardiovascular risk in humans. Obesity, 15(6):1473-1483.

[78]Nakachi, K., Matsuyama, S., Miyake, S., et al., 2000. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors, 13(1-4):49-54.

[79]Nakagawa, K., Miyazawa, T., 1997. Absorption and distribution of tea catechin, (‒)-epigallocatechin-3-gallate, in the rat. J. Nutr. Sci. Vitaminol., 43(6):679-684.

[80]Nurk, E., Refsum, H., Drevon, C.A., et al., 2009. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J. Nutr., 139(1):120-127.

[81]Oak, M.H., Bedoui, J.E., Schini-Kerth, V.B., 2005. Antiagiogenic properties of natural polyphenols from red wine and green tea. J. Nutr. Biochem., 16(1):1-8.

[82]Ogunleye, A.A., Xue, F., Michels, K.B., 2010. Green tea consumption and breast cancer risk of recurrence: a meta-analysis. Breast Cancer Res. Treat., 119(2):477-484.

[83]Ogura, R., Ikeda, N., Yuki, K., et al., 2008. Genotoxicity studies on green tea catechin. Food Chem. Toxicol., 46(6):2190-2200.

[84]Ohno, Y., Wakai, K., Genka, K., 1995. Tea consumption and lung cancer risk: a case-control study in Okinawa, Japan. Jpn. J. Cancer Res., 86(11):1027-1034.

[85]Oi, Y., Hou, I.C., Fujita, H., et al., 2012. Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid. Phytother. Res., 26(4):475-481.

[86]Osanai, K., Landis-Piwowar, K.R., Dou, Q.P., et al., 2007. A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer celosis inducer. Bioorg. Med. Chem., 15:492-496.

[87]Pearson, D.A., Frakel, E.N., Aeschbach, R., et al., 1998. Inhibition of endothelial cell mediated low-density lipoprotein oxidation by green tea extracts. J. Agric. Food Chem., 46(4):1445-1449.

[88]Pham-Huy, L.A.N., He, H., Pham-Huy, C., 2008. Green tea and health: an overview. J. Food Agric. Environ., 6(1):6-13.

[89]Phung, O.J., Baker, W.L., Matthews, L.J., et al., 2010. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am. J. Clin. Nutr., 91(1):73-81.

[90]Potenza, M.A., Marasciulo, F.L., Tarquinio, M., et al., 2007. EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am. J. Physiol. Endocrinol. Metab., 292(5):E1378-E1387.

[91]Rodriguez, S.K., Guo, W., Liu, L., et al., 2006. Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex. Int. J. Cancer, 118(7):1635-1644.

[92]Sae-tan, S., Grove, K.A., Lambert, J.D., 2011. Weight control and prevention of metabolic syndrome by green tea. Phamacol. Res., 64(2):146-154.

[93]Saleh, I.G., Ali, Z., Abe, N., et al., 2013. Effect of green tea and its polyphenols on mouse liver. Fitoterapia, 90: 151-159.

[94]Sano, J., Inami, S., Seimiya, K., et al., 2004. Effects of green tea intake on the development of coronary artery disease. Circul. J., 68(7):665-670.

[95]Sarma, D.N., Barrett, M.L., Chavez, M.L., et al., 2008. Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Safety, 31(6):469-484.

[96]Schönthal, A.H., 2011. Adverse effects of concentrated green tea extracts. Mol. Nutr. Food Res., 55(6):874-885.

[97]Seely, D., Mills, E.J., Wu, P., et al., 2005. The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systemic review and meta-analysis. Integr. Cancer Ther., 4(2):144-155.

[98]Shimizu, M., Deguchi, A., Hara, Y., et al., 2005. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem. Biophys. Res. Commun., 334(3):947-953.

[99]Shrubsole, M.J., Lu, W., Chen, Z., et al., 2009. Drinking green tea modestly reduces breast cancer risk. J. Nutr., 139(2):310-316.

[100]Shutava, T.G., Balkundi, S.S., Vangala, P., et al., 2009. Layer-by-layer-coated gelatin nanoparticles as a vehicle for delivery of natural polyphenols. ACS Nano, 3(7):1877-1885.

[101]Siddiqui, I.A., Adhami, V.M., Bharali, D.J., et al., 2009. Introducing nanochemoprervention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Res., 69(5):1712-1716.

[102]Siddiqui, I.A., Adhami, V.M., Ahmad, N., et al., 2010. Nanochemoprervention: sustained release of bioactive food components for cancer prevention. Nutr. Cancer, 62(7):883-890.

[103]Song, Y., Manson, J.E., Buring, J.E., et al., 2005. Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J. Am. Coll. Nutr., 24(5):376-384.

[104]Suganuma, M., Okabe, S., Marino, M.W., et al., 1999. Essential role of tumor necrosis factor-α (TNF-α) in tumor promotion as revealed by TNF-α-deficient mice. Cancer Res., 59(18):4516-4518.

[105]Suganuma, M., Okabe, S., Kai, Y., et al., 2010. Synergistic effects of (−)-epigallocatechin-3-gallate with (−)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Res., 59(1):44-47.

[106]Suganuma, M., Saha, A., Fujiki, H., 2011. New cancer treatment stratedy using combination of green tea catechins and anticancer drugs. Cancer Sci., 102(2):317-323

[107]Sun, C.L., Yuan, J.M., Lee, M.J., et al., 2002. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. Carcinogenensis, 23(9):1497-1503.

[108]Sun, C.L., Yuan, J.M., Koh, W.P., et al., 2006. Green tea and black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis, 27(7):1301-1309.

[109]Sun, C.L., Yuan, J.M., Koh, W.P., et al., 2007. Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study. Carcinogenesis, 28(10):2143-2148.

[110]Suzuki, Y., Tsubono, Y., Nakaya, N., et al., 2004. Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan. Br. J. Cancer, 90(7):1361-1363.

[111]Tan, E.K., Tan, C., Fook-Chong, S.M., et al., 2003. Dose-dependent protective effect of coffee, tea, and smoking in Parkinson’s disease: a study in ethnic Chinese. J. Neurol. Sci., 216(1):163-167.

[112]Tang, N., Wu, Y., Zhou, B., et al., 2009. Green tea, black tea consumption and risk of lung cancer: a meta-analysis. Lung Cancer, 65(3):274-283.

[113]Thielecke, F., Boschmann, M., 2009. The potential role of green tea catechins in the prevention of the metabolic syndrome—a review. Phytochemistry, 70(1):11-24.

[114]Tsuneki, H., Ishizuka, M., Terasawa, M., et al., 2004. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC pharmacol., 4(1):18.

[115]Ullmann, U., Haller, J., Decourt, J.P., et al., 2003. A single ascending dose study of epigallocatechin gallate in healthy volunteers. J. Int. Med. Res., 31(2):88-101.

[116]Unno, T., Suzuki, Y., Kakuda, T., et al., 1999. Metabolism of theanine, γ-glutamylethylamide, in rats. J. Agric. Food Chem., 47(4):1593-1596.

[117]Venables, M.C., Hulstron, C.J., Cox, H.R., et al., 2008. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am. J. Clin. Nutr., 87(3):778-784.

[118]Vernarelli, J.A., Lambert, J.D., 2013. Tea consumption is inversely associated with weight status and other markers for metabolic syndrome in US adults. Eur. J. Nutr., 52(3):1039-1048.

[119]Vita, J.A., 2003. Tea consumption and cardiovascular disease: effects on endothelial function. J. Nutr., 133(10):3293S-3297S.

[120]Wang, H., Wen, Y., Du, Y., et al., 2010. Effect of catechin enriched green tea on body composition. Obesity, 18(4):773-779.

[121]Wu, A.H., Yu, M.C., 2006. Tea, hormone-related cancers and endogenous hormone levels. Mol. Nutr. Food Res., 50(2):160-169.

[122]Wu, A.H., Butler, L.M., 2011. Green tea and breast cancer. Mol. Nutr. Food Res., 55(6):921-930.

[123]Wu, A.H., Yu, M.C., Tseng, C.C., et al., 2003. Green tea and risk of breast cancer in Asian Americans. Int. J. Cancer, 106(4):574-579.

[124]Wu, A.H., Yu, M.C., Tseng, C.C., et al., 2007. Body size, hormone therapy and risk of breast cancer in Asian American women. Int. J. Cancer, 120(4):844-852.

[125]Wu, C.H., Lu, F.H., Chang, T.C., et al., 2003. Relationship among habitual tea consumption, percent body fat, and body fat distribution. Obesity, 11(9):1088-1095.

[126]Xu, R., Ye, H., Sun, Y., et al., 2012. Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food Chem. Toxicol., 50(7):2473-2480.

[127]Yang, C.S., Hong, J., 2013. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Ann. Rev. Nutr., 33(1):161-181.

[128]Yang, C.S., Lee, M.J., Chen, L., et al., 1999. Human salivary tea catechin levels and catechin esterase activities implication in human cancer prevention studies. Cancer Epidemiol. Biomarkers Prev., 8(1):83-89.

[129]Yang, C.S., Lu, F.H., Wu, J.S., et al., 2004. The protective effect of habitual tea consumption on hypertension. Arch. Intern. Med., 164(14):1534-1540.

[130]Yang, C.S., Lambert, J.D., Hou, Z., et al., 2006. Molecular targets for the cancer preventive activity of tea polyphenols. Mol. Carcinog., 45(6):431-435.

[131]Yang, C.S., Wang, X., Lu, G., et al., 2009. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat. Rev. Cancer, 9(6):429-439.

[132]Yang, C.S., Wang, H., Li, G.X., et al., 2011. Cancer prevention by tea: evidence from laboratory studies. Pharmacol. Res., 64(2):113-122.

[133]Yang, G., Shu, X.O., Li, H., et al., 2007. Prospective cohort study of green tea consumption and colorectal cancer risk in women. Cancer Epidemiol. Biomarkers Prev., 16(6):1219-1223.

[134]Yuan, J.M., Koh, W.P., Sun, C.L., et al., 2005. Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore. Carcinogenesis, 26(8):1389-1394.

[135]Yuan, J.M., Sun, C., Butler, L.M., 2011. Tea and cancer prevention: epidemiological studies. Pharmacol. Res., 64(2):123-135.

[136]Yusuf, S., Hawken, S., Ôunpuu, S., et al., 2005. Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study. Lancet, 366(9497):1640-1649.

[137]Zhang, M., Holman, C.D., Huang, J.P., et al., 2007. Green tea and the prevention of breast cancer: a case-control study in Southeast China. Carcinogenesis, 28(5):1074-1078.

[138]Zhou, Y., Li, N., Zhuang, W., et al., 2008. Green tea and gastric cancer risk: meta-analysis of epidemiologic studies. Asia Pac. J. Clin. Nutr., 17(1):159-165.