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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

2016 Vol.17 No.5 P.333-341

Multifunctional protein: cardiac ankyrin repeat protein

Na Zhang, Xiao-jie Xie, Jian-an Wang

Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

jian_an_wang@yahoo.com

Abstract: Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.

Key words: Cardiac ankyrin repeat protein (CARP), Cardiovascular disease, Cardiac development

Chinese Summary  <785> 心锚重复蛋白的研究进展

概要：心锚重复蛋白（CARP）是一个双重定位的蛋白，既可以在胞浆中作为肌节的结构组成蛋白，又定位于细胞核中作为转录共刺激因子调节其他基因的表达。研究发现CARP在多种心血管疾病及肌肉疾病中表达升高，但其在疾病中的作用尚存在争议。本文就CARP的研究进展进行综述，概述CARP的发现过程和结构，并对CARP在疾病中的作用的争议进行总结分析。

关键词组：心锚重复蛋白；心血管疾病；心脏发育


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DOI:

10.1631/jzus.B1500247

CLC number:

R34

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On-line Access:

2016-05-04

Received:

2015-10-12

Revision Accepted:

2015-12-02

Crosschecked:

2016-04-11

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