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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2016 Vol.17 No.10 P.798-806
Visualization analysis of CRISPR/Cas9 gene editing technology studies
Abstract: The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system is an adaptive immune defense system that resists the invasion of viruses and plasmids heterologous genetic material in bacteria and archaea. Taking the literature related to gene editing technology of CRISPR/Cas9 from the Web of Science database from 2002 to 2015, we use the software CiteSpaceV to analyze co-cited literature in order to establish the research hotspots and fronts recently in this field by knowledge mapping.
Key words: CRISPR/Cas9, CiteSpaceV, Visualization analysis
创新点：CRISPR/Cas9系统是细菌和古细菌在长期演化过程中形成的一种抵御异源遗传物质入侵的适应性免疫防御机制。它被广泛应用于人类细胞、小鼠、斑马鱼、大米等的基因定向改造。本研究利用信息可视化软件CiteSpaceV分析了近年发表的CRISPR/Cas9有关文献，并绘制了知识图谱。
方法：基于Web of Science数据库中2002年至2015年有关基因编辑技术CRISPR/Cas9的文献资料为研究对象。利用信息可视化软件CiteSpaceV进行共被引文献分析，以知识图谱方式展现该领域近年来的研究热点和前沿。
结论：CRISPR/Cas9系统的历史研究充分表明跨学科的重要性。跨学科点通常是新的科学的增长点和新的科学前沿，这是最有可能产生显著科学突破的地方。
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Open peer comments: Debate/Discuss/Question/Opinion
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DOI:
10.1631/jzus.B1601985
CLC number:
Q78; G35
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On-line Access:
2016-10-02
Received:
2016-08-12
Revision Accepted:
2016-08-28
Crosschecked:
2016-09-11