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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

Role of cytoplasmic lncRNAs in regulating cancer signaling pathways

Abstract: Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.

Key words: Long noncoding RNA (lncRNA); Cancer signaling; Cancer therapy; Biomarker

Chinese Summary  <27> 细胞质lncRNAs与肿瘤信号调控

关键词组:长链非编码RNAs(lncRNAs);信号转导;肿瘤标志物;肿瘤靶点


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DOI:

10.1631/jzus.B1800254

CLC number:

Q39

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On-line Access:

2019-01-07

Received:

2018-04-27

Revision Accepted:

2018-09-16

Crosschecked:

2018-12-05

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