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Lymphatic vasculature in tumor metastasis and immunobiology

Abstract: Lymphatic vessels are essential for tissue fluid homeostasis, immune cell trafficking, and intestinal lipid absorption. The lymphatics have long been recognized to serve as conduits for distant tumor dissemination. However, recent findings suggest that the regional lymphatic vasculature also shapes the immune microenvironment of the tumor mass and potentiates immunotherapy. This review discusses the role of lymphatic vessels in tumor metastasis and tumor immunity.

Key words: Lymphatic; Lymphatic endothelial cell (LEC); Cancer; Metastasis; Immunotherapy

Chinese Summary  <113> 淋巴血管在肿瘤转移和免疫生物学中的作用

关键词组:淋巴系统;淋巴内皮细胞;肿瘤;转移;免疫治疗


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DOI:

10.1631/jzus.B1800633

CLC number:

R730.2

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On-line Access:

2020-01-03

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