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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2020 Vol.21 No.2 P.166-171
CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord
Abstract: Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA’s underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).
Key words: FKN/CX3CR1; Mechanical allodynia; STZ-induced diabetic mice
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DOI:
10.1631/jzus.B1900439
CLC number:
R587.2
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On-line Access:
2020-03-02
Received:
2019-07-19
Revision Accepted:
2019-11-12
Crosschecked:
2020-02-04