Abstract: Hearing impairment has become one of the most common sensory disabilities. The World Health Organization (WHO) estimates that 466 million people were living with disabling hearing loss in 2018, and that number could rise to 900 million by 2050. Conductive hearing loss, which predominantly involves the sound-transmitting route of the outer and middle ear, has been well handled by antibiotics and surgery. However, sensorineural hearing loss, which involves the inner ear and structures further within the auditory pathway, has very limited biological treatment options (current treatment options include only hearing amplification and cochlear implants). Part of the reason for the paucity of therapeutics is due to the complexity of the auditory system and the limited regenerative ability of the hearing sensory cells, hair cells, and connected nerve.

Key words: Hearing impairment; Auditory; Special feature

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