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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2023 Vol.24 No.12 P.1123-1140
Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer
Abstract: Breast cancer is a malignant tumor that seriously endangers women’s lives. The prognosis of breast cancer patients differs among molecular types. Compared with other subtypes, triple-negative breast cancer (TNBC) has been a research hotspot in recent years because of its high degree of malignancy, strong invasiveness, rapid progression, easy of recurrence, distant metastasis, poor prognosis, and high mortality. Many studies have found that long non-coding RNA (lncRNA) plays an important role in the occurrence, proliferation, migration, recurrence, chemotherapy resistance, and other characteristics of TNBC. Some lncRNAs are expected to become biomarkers in the diagnosis and prognosis of TNBC, and even new targets for its treatment. Based on a PubMed literature search, this review summarizes the progress in research on lncRNAs in TNBC and discusses their roles in TNBC diagnosis, prognosis, and chemotherapy with the hope of providing help for future research.
Key words: Triple-negative breast cancer (TNBC); Long non-coding RNA (lncRNA); Diagnosis; Prognosis; Chemotherapy resistance
1浙江省肿瘤医院乳腺外科，中国科学院杭州医学研究所，中国杭州市，310022
2温州医科大学研究生培养基地（浙江省肿瘤医院），中国杭州市，310022
3山西医科大学，中国晋中市，030600
摘要：乳腺癌是一种严重危害女性生命的恶性肿瘤。乳腺癌患者的预后因分子类型而异，与其它亚型相比，三阴性乳腺癌（TNBC）因其恶性程度高、侵袭性强、进展快、易复发、易远处转移、预后差和死亡率高而成为近年来的研究热点。许多研究发现，长链非编码RNAs（lncRNAs）在TNBC的发生、增殖、迁移、复发和化疗耐药性等方面起着重要作用。一些lncRNAs有望成为TNBC诊断和预后判断的生物学标志物，甚至成为治疗的新靶点。本文在PubMed文献检索的基础上，总结了lncRNAs在TNBC中的研究进展，并讨论了它们在TNBC诊断、预后和化疗中的作用，希望为未来的研究提供帮助。
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DOI:
10.1631/jzus.B2300067
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On-line Access:
2024-08-27
Received:
2023-10-17
Revision Accepted:
2024-05-08
Crosschecked:
2023-12-12