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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2023 Vol.24 No.12 P.1159-1164
Typical hemophagocytic syndrome associated with cytomegalovirus infection in an immunocompetent patient: a case report and literature review
Abstract: Cytomegalovirus (CMV) infection is currently prevalent in populations throughout the world, and 56%–94% of the global population is seropositive for CMV. CMV infection mainly affects immunocompromised hosts. In these cases, it can cause significant symptoms, tissue-invasive disease, and many sequelae including death (Dioverti and Razonable, 2016). The vast majority of healthy adults with CMV infection experience an asymptomatic course; when symptomatic, it manifests as a mononucleosis-like syndrome in approximately 10% of patients (Sridhar et al., 2018). The gastrointestinal tract and central nervous system appear to be the most frequent sites of severe CMV infection in immunocompetent individuals (Rafailidis et al., 2008). However, CMV infection is relatively rarely recorded in immunocompetent hosts.
Key words: Cytomegalovirus infection; hemophagocytic lymphohistiocytosis; ruxolitinib; immunocompetent
1浙江大学医学院附属第一医院感染科，传染病诊治国家重点实验室，国家感染性疾病临床医学研究中心，国家传染病医学中心，感染性疾病诊治协同创新中心，中国杭州市，310003
2浙江大学医学院附属第一医院血液科，中国杭州市，310003
摘要：嗜血细胞综合征是一种罕见的因大量免疫细胞不受控制的激活和增殖以及细胞因子风暴引起的致命性疾病。尽管病毒感染是其常见病因，但由巨细胞病毒引起的嗜血细胞综合征较为少见。巨细胞病毒感染通常可在免疫功能低下或缺陷人群中引起系列疾病，而在免疫功能正常人群中多表现为无症状。本文报道了一例免疫功能正常患者感染巨细胞病毒引起嗜血细胞综合征后，经芦可替尼治疗成功好转。本文旨在强调免疫功能正常患者感染巨细胞病毒后可引起严重的嗜血细胞综合征，而及时给予芦可替尼治疗可以显著改善患者预后。同时，应进一步提高临床医师对免疫功能正常人群感染巨细胞病毒的重视，并为临床工作者提供新的诊疗思路。
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DOI:
10.1631/jzus.B2300232
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On-line Access:
2024-08-27
Received:
2023-10-17
Revision Accepted:
2024-05-08
Crosschecked:
2023-12-12