|
|
Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2025 Vol.26 No.10 P.995-1014
Pediatric inflammatory bowel disease in mother‒child pairs: clinical risk factors and gut microbiota characteristics
Abstract: ObjectiveThe risk factors and role of mother-child gut microbiota in pediatric inflammatory bowel disease (PIBD) remain unclear. We aimed to explore the clinical risk factors associated with PIBD, analyze the characteristics of gut microbiota of children and their mothers, and examine the correlation of the microbial composition in mother-child pairs.
MethodsWe conducted a case-control study including children with PIBD and their mothers as the case group, as well as healthy children and their mothers as the control group. Questionnaires were used to collect information such as family illness history and maternal and early-life events. Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA (rRNA) sequencing to analyze the composition and its potential association with PIBD.
ResultsA total of 54 pairs of cases and 122 pairs of controls were recruited. A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD, and a higher education level of the father was associated with a decreased risk of PIBD. Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers. Similarities were observed in the gut microbiota of mothers and children in the same groups. Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.
ConclusionsPIBD is influenced by maternal risk factors and has unique gut microbiota characteristics. The mother-child gut microbiota is closely related, suggesting the transmission and influence of the gut microbiota between mothers and children. This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.
Key words: Inflammatory bowel disease (IBD); Risk factor; Gut microbiota; Mother-child pair
1北京大学第三医院消化科，中国北京市，100191
2幽门螺杆菌感染及上胃肠疾病诊治研究北京市重点实验室，中国北京市，100191
3北京大学第三医院儿科，中国北京市，100191
4首都儿科研究所消化科，中国北京市，100020
摘要：在儿童炎症性肠病（PIBD）发病中，母子肠道菌群的作用及相关风险因素尚未明确。本研究旨在探究PIBD发病的临床危险因素，分析患儿与母亲的肠道菌群特征，并探讨二者肠道菌群的相关性。研究采用病例-对照设计，纳入54对PIBD患儿及其母亲作为病例组，122对健康儿童及其母亲作为对照组。通过问卷收集家族疾病史、围产期及生命早期事件等信息；采集两组儿童及母亲的粪便样本，进行微生物16S rRNA测序，分析肠道菌群组成及其与PIBD发病的潜在关联。结果显示，自身免疫病家族史、孕期抗生素使用与PIBD发病风险升高相关，而父亲学历较高则与PIBD发病风险降低相关。病例组母子的肠道菌群与对照组存在显著差异，且同组内母亲与子女的肠道菌群具有相似性。此外，母亲的肠道菌群生物标志物可预测其子女患PIBD的风险。综上，PIBD的发病受母源性危险因素影响，患者存在独特的肠道菌群特征；母子肠道菌群的密切关联提示二者间存在菌群传递与相互影响。本研究为阐明PIBD的潜在发病机制提供了依据，并为针对性干预措施的开发奠定了基础。
关键词组：
References:
Open peer comments: Debate/Discuss/Question/Opinion
<1>
DOI:
10.1631/jzus.B2400330
CLC number:
Download Full Text:
Downloaded:
2629
Download summary:
<Click Here>Downloaded:
232Clicked:
2470
Cited:
0
On-line Access:
2025-10-21
Received:
2024-06-25
Revision Accepted:
2024-08-26
Crosschecked:
2025-10-21