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Journal of Zhejiang University SCIENCE B

ISSN 1673-1581(Print), 1862-1783(Online), Monthly

Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

Abstract: Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1), and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of Citrus on oxidative stress and lipid metabolism, aiming to provide new insights for promoting female reproductive health; however, further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.

Key words: Citrus; Food; Female reproductive health; Oxidative stress; Lipid metabolism

Chinese Summary  <14> 柑橘对氧化应激和脂质代谢调节的影响及其改善女性生殖健康的潜力

杨亦岩,周珏
浙江工商大学食品与生物工程学院,中国杭州市,310018
摘要:柑橘在国际上拥有悠久的食用历史,广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用,这些因素与女性生殖健康密切相关。研究表明,柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激,并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响,旨在为促进女性生殖健康提供新思路。然而,仍需进一步的研究明确其作用机制,且柑橘活性成分的临床治疗潜力仍有待验证。

关键词组:柑橘;食品;女性生殖健康;氧化应激;脂质代谢


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DOI:

10.1631/jzus.B2500127

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On-line Access:

2025-08-25

Received:

2025-03-17

Revision Accepted:

2025-05-27

Crosschecked:

2025-08-25

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