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Journal of Zhejiang University SCIENCE B
ISSN 1673-1581(Print), 1862-1783(Online), Monthly
2025 Vol.26 No.7 P.613-632
Small fish making a big difference: beloved star of environmental toxicology research in the current era
Abstract: The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications. This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology, highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms. The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways. By incorporating cutting-edge technologies such as artificial intelligence (AI), high-throughput screening, and omics approaches, the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations, promote environmental conservation efforts, contribute to safeguarding human health, and advance sustainable development objectives.
Key words: Zebrafish model; Environmental toxicant; Environmental toxicology
1浙江大学医学院附属儿童医院遗传与代谢病科,国家儿童健康与疾病临床医学研究中心,中国杭州市,310003
2浙江大学生命科学学院, 浙江省细胞与基因工程重点实验室,中国杭州市,310058
摘要:斑马鱼凭借其独特的生物学特性和广泛的应用价值,已成为生命科学研究中的重要模式生物。本综述全面概述了斑马鱼在环境毒理学领域的最新研究进展,并重点介绍了利用该物种探究各类污染物的生态影响及其作用机制的代表性成果。这些研究充分印证了斑马鱼作为模式生物在揭示环境污染的生态效应与毒性通路方面的重要潜力。通过融合人工智能、高通量筛选及多组学分析等前沿技术,斑马鱼模型的应用将显著加速毒理学研究进程,推动环境保护实践,助力人类健康保障,并推进可持续发展目标的实现。
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DOI:
10.1631/jzus.B2500166
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On-line Access:
2025-07-28
Received:
2025-04-03
Revision Accepted:
2025-05-01
Crosschecked:
2025-07-28