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Frontiers of Information Technology & Electronic Engineering
ISSN 2095-9184 (print), ISSN 2095-9230 (online)
2024 Vol.25 No.12 P.1723-1731
Effective degree of freedom for near-field plane-based XL-MIMO with tri-polarization
Abstract: In this paper we study the effective degree of freedom (EDoF) for extremely large-scale multiple-input multiple-output (XL-MIMO) systems. We consider two XL-MIMO hardware designs, uniform planar array (UPA) based and continuous aperture (CAP) based XL-MIMO, as well as two representative near-field channel models: scalar Green function based and dyadic Green function with triple polarization based models. First, for UPA-based XL-MIMO with a discrete array aperture, we evaluate the EDoF performance by applying discrete channel matrices generated by the scalar or dyadic Green channel model. Then, for CAP-based XL-MIMO, a tailored EDoF performance evaluation framework for a two-dimensional (2D) CAP plane based system is constructed by leveraging asymptotic analysis and extending the analysis approaches for a one-dimensional (1D) CAP line segment based system. This framework incorporates the triple-polarized auto-correlation kernel function, which can efficiently capture the impact of multiple polarization on the EDoF performance. Numerical results show that, with an increase in the number of antennas, the UPA-based XL-MIMO system can achieve an EDoF performance close to the EDoF performance for the CAP plane based XL-MIMO system. Moreover, the EDoF performance can be enhanced by the multiple polarization in channels and increased physical size of the transceiver.
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1杭州医学院附属人民医院,浙江省人民医院,输血科,实验医学中心,过敏中心,杭州医学院,中国杭州市,310014
2浙江省生物标志物与体外诊断转化重点实验室,中国杭州市,310063
3浙江工业大学药学院,中国杭州市,310014
4浙江大学医学院附属第一医院生物物理系,神经外科,中国杭州市,310058
5浙江中医药大学附属第三医院,中国杭州市,310005
摘要:蛋白激酶C相互作用蛋白1(PICK1)与多种参与神经系统疾病和多种癌症的膜蛋白和受体存在相互作用。然而,PICK1在胃癌中的作用仍不清楚。本研究旨在探讨PICK1在胃癌中的表达以及与Toll样受体4(TLR4)的相互作用。临床数据分析显示,肿瘤部位PICK1表达水平下降,可预测胃癌患者不良预后。高表达PICK1可抑制胃癌细胞的增殖和迁移,该作用依赖于TLR4/MyD88信号通路。此外,体外实验表明,PICK1影响TLR4的转运和降解,并通过自噬促进胃癌细胞中TLR4的降解。分子动力学模拟强调了TLR4-PICK1复合物的结合强度和稳定性。本研究为阐明PICK1在胃癌中的细胞和病理功能提供了新的见解。
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DOI:
10.1631/FITEE.2400167
CLC number:
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On-line Access:
2025-01-24
Received:
2024-03-07
Revision Accepted:
2025-01-24
Crosschecked:
2024-08-08