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Frontiers of Information Technology & Electronic Engineering

ISSN 2095-9184 (print), ISSN 2095-9230 (online)

Output difference feedback and system benefit control based dynamic heterogeneous redundancy architecture

Abstract: Mimic active defense technology effectively disrupts attack routes and reduces the probability of successful attacks by using a dynamic heterogeneous redundancy (DHR) architecture. However, current approaches often overlook the adaptability of the adjudication mechanism in complex and variable network environments, focusing primarily on system security while neglecting performance considerations. To address these limitations, we propose an output difference feedback and system benefit control based DHR architecture. This architecture introduces an adjudication mechanism based on output difference feedback, which enhances adaptability by considering the impact of each executor’s output deviation on the global decision. Additionally, the architecture incorporates a scheduling strategy based on system benefit, which models the quality of service and switching overhead as a bi-objective optimization problem, balancing security with reduced computational costs and system overhead. Simulation results demonstrate that our architecture improves adaptability towards different network environments and effectively reduces both the attack success rate and average failure rate.

Key words: Mimic defense; Adjudication mechanism; Scheduling strategy; Executor output difference; System benefit

Chinese Summary  <7> Wnt配体和受体在口腔鳞状细胞癌中的作用

穆罕默德·图法尔1, 何彩云1, 蒋灿华1,2,3,4, 李宁1,2,3,4
1中南大学湘雅医院口腔颌面外科, 口腔医学中心, 中国长沙市, 410008
2中南大学口腔癌前病变研究所, 中国长沙市, 410008
3中南大学湘雅医院口腔与颌面肿瘤研究中心, 中国长沙市, 410008
4中南大学湘雅医院老年病国家临床研究中心, 中国长沙市, 410008
摘要:口腔鳞状细胞癌(OSCC)具有较高发病率和死亡率,在临床诊断和治疗中面临重大挑战。最新研究证实Wnt配体及其受体在OSCC发病中具有关键作用。Wnt信号通路失调可通过促进细胞增殖和上皮-间质转化(EMT),以及维持癌症干细胞(CSC)干性,来驱动肿瘤的发生与发展,并导致其产生治疗抵抗。尽管靶向Wnt信号通路展现出潜在的治疗前景,但要实现有效干预,仍需对Wnt与其他信号通路的复杂相互作用展开进一步研究。本文对Wnt配体和受体在OSCC中作用的最新研究进行综述,强调其作为诊断生物标志物和治疗靶点的潜力。未来的研究方向包括阐明Wnt信号通路在特定背景下的动态变化,并探索联合疗法以提高OSCC患者的临床治疗效果。

关键词组:口腔鳞状细胞癌(OSCC);Wnt信号通路;分子机制;肿瘤发生;治疗靶点


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DOI:

10.1631/FITEE.2400251

CLC number:

TP393

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On-line Access:

2025-06-04

Received:

2024-04-02

Revision Accepted:

2024-10-22

Crosschecked:

2025-09-04

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