Abstract: To study the relationship between ulcer recurrence and Helicobacter Pylori. 147 patients with peptic ulcer were divided into H. Pylori infected group and H.pylori uninfected group by rapid urease test, serum antibody examination and histopathology of gastric biopsy specimens. We assigned all patients to receive dual oral therapy with omeprazole 40 mg/day for 4 weeks and amoxicillin 2000 mg/day for 2 weeks. To all patients, repeated gastroscope was performed at 8 weeks and one-year after beginning therapy to record whether the ulcer was cured. Endoscopic biopsy was also performed to dertermine H.pylori status. One year later, H.pylori positive patients had a higher ulcer recurrent rate than H.pylori negative patients(23.33% vs 2.70%; P=0.001). Ulcer recurrence was closely related to H.pylori infection. H.pylori was the risk factor for ulcer relapse.

Key words: H. pylori reinfection, peptic ulcer/relapse

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