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Journal of Zhejiang University SCIENCE A
ISSN 1673-565X(Print), 1862-1775(Online), Monthly
2001 Vol.2 No.1 P.107-110
EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
Abstract: To study the function of transforming growth factor β1 (TGF-β1) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β1, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.
Key words: colorectal adenomas,TGF-β1,TGF-βR II,immunohistochemistry
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DOI:
10.1631/jzus.2001.0107
CLC number:
R574
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2024-08-27
Received:
2023-10-17
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2024-05-08
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