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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

2001 Vol.2 No.3 P.275-277

A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1'-BI-2-NAPHTHOL

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Abstract: An improved method for preparing enantiomerically pure 1,1'-bi-2-naphthols is described. 1,1'-bi-2-naphthol boric anhydride was generated from the reaction of racemic 1,1'-bi-2-naphthol and boric anhydride. Its two diastereoisomers could be efficiently separated in THF using (L)-proline as the resolving agent. Treatment in three successive steps yielded 79% and 74% enantiomerically pure (S)- and (R)-1,1'-bi-2-naphthol respectively.

Key words: 1,1'-bi-2-naphthol, chiral resolution


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DOI:

10.1631/jzus.2001.0275

CLC number:

O621.14+4

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On-line Access:

2024-08-27

Received:

2023-10-17

Revision Accepted:

2024-05-08

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