Abstract: The authors investigated the influence of green tea polyphenols (GTPs) on the liver mitochondria permeability transition pore (PTP) opening through mit ochondria swelling and change of mitochondria membrane potential. The data showed that GTPs had obvious protective effect on the Ca²⁺-induced PTP opening in a dose-dependent manner detected by mitochondria swelling. The results were obtained by measuring the change of mitochondria membrane potential through Rh 123. Further experiments were conducted to examine the detailed influence of GTPs on Ca²⁺ import and export of mitochondria. The results showed that GTPs had remarkably inhibitory effect on the Ca²⁺-induced Ca²⁺ import in mitochondria; and that they could accelerate Ca²⁺-release from mitochondria. Our data provide an alternate interpretation of the potent protective function of GTPs on cell against apoptosis.

Key words: Mitochondria, PTP green tea polyphenols, mCICR, Ca²⁺ transport, Mitochondria ΔΨ_m

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