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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

2004 Vol.5 No.2 P.186-192

A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway

LIN Xin-da, LIN Xin-hua, CHENG Jia-an

Institute of Applied Entomology, Zhejiang University, Hangzhou 310029, China; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA

linxinda@yahoo.com; linxh@uc.edu; jacheng@sun.zju.edu.cn

Abstract: A wing specific F1 genetic screen was carried out using the powerfulDrosophila genetic system, combined with yeast FRT/FLP and GAL4/UAS system. Form the wing phenotypes and germline clone embryonic cuticle phenotypes observed in these mutant alleles, a number of mutant alleles of known or unknown genes were isolated. Among them, fifteen mutant alleles related to Wingless signal transduction were further isolated; the arm of these mutations located were determined, and their location in the chromosome were roughly mapped.

Key words: Drosophila, Genetic screen, Wingless signal transduction, Mutant allele

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DOI:

10.1631/jzus.2004.0186

CLC number:

Q344.5

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Received:

2003-03-04

Revision Accepted:

2003-05-05

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