Abstract: In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D₃ on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D₃ on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D₃ on dendritic cells.

Key words: 1,25-dihydroxyvitamin D3, Dendritic cells, Gene expression, cDNA array

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