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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

2004 Vol.5 No.10 P.1245-1248

Effects of vanadate on the activities of mice glucokinase and hexokinase

XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei

Department of Endocrinology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Medical Nutrition and Food Hygiene Graduate School, Zhejiang University, Hangzhou 310031, China; Division of Life Sciences, City College, Zhejiang University, Hangzhou 310015, China; Department of Isotopology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China

xu921@21cn.com

Abstract: This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.

Key words: Sodium metavanadate (SMV), Glucokinase, Hexokinase, Blood glucose, Insulin


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DOI:

10.1631/jzus.2004.1245

CLC number:

R587.1

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2003-07-14

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