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Journal of Zhejiang University SCIENCE A

ISSN 1673-565X(Print), 1862-1775(Online), Monthly

2004 Vol.5 No.12 P.1509-1511

Synthesis of arbutin by two-step reaction from glucose

HUANG Shen-lin, ZHU Yu-lin, PAN Yuan-jiang, WU Shi-hua

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

panyuanjiang@zju.edu.cn

Abstract: Arbutin was synthesized from glucose by two-step reaction below: (a) 2,3,4,6-tetra-O-acetyl-α-D-glucosyl chloride or bromide was prepared by glucose and acetyl halide (chloride or bromide). (b) 2,3,4,6-tetra-O-acetyl-α-D-glucosyl halide (Cl, Br) reacted with hydroquinone, methanol as solvent at pH=9.5~10.0.

Key words: Arbutin, Synthesis, 2,3,4,6-tetra-O-acetyl-α-D-glucosyl halide (chloride or bromide), Acetyl halide (Cl, Br)


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Open peer comments: Debate/Discuss/Question/Opinion

<1>

Pierre@Lille<pierro_insomnia_005@hotmail.fr>

2014-11-18 17:27:12

phD student in organic chemistry

BIPIN@shah<dr.bpshah@vihita.com>

2014-07-27 14:49:18

Good paper
thank you
i am very happy

BIPIN@shah<dr.bpshah@vihita.com>

2014-07-27 14:46:51

good paper

dhassida@No address<dhassida\_t@yahoo.com>

2012-09-11 00:22:13

synthesis procedure

ezat@hussein<ezat_ahlam@yahoo.com>

2010-10-30 02:22:38

my name is ezat ,ihave ph.D in organic chemistry from baghdad university

waheed @in<waheedkhan@hotmail.co.in>

2010-10-21 20:00:07

reaction mechanism

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DOI:

10.1631/jzus.2004.1509

CLC number:

O621.3

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